Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971461609> ?p ?o ?g. }
- W1971461609 endingPage "e864" @default.
- W1971461609 startingPage "e864" @default.
- W1971461609 abstract "Loss of the cell polarity gene could cooperate with oncogenic Ras to drive tumor growth and invasion, which critically depends on the c-Jun N-terminal Kinase (JNK) signaling pathway in Drosophila. By performing a genetic screen, we have identified Src42A, the ortholog of mammalian Src, as a key modulator of both RasV12/lgl−/− triggered tumor invasion and loss of cell polarity gene-induced cell migration. Our genetic study further demonstrated that the Bendless (Ben)/dUev1a ubiquitin E2 complex is an essential regulator of Src42A-induced, JNK-mediated cell migration. Furthermore, we showed that ectopic Ben/dUev1a expression induced invasive cell migration along with increased MMP1 production in wing disc epithelia. Moreover, Ben/dUev1a could cooperate with RasV12 to promote tumor overgrowth and invasion. In addition, we found that the Ben/dUev1a complex is required for ectopic Src42A-triggered cell death and endogenous Src42A-dependent thorax closure. Our data not only provide a mechanistic insight into the role of Src in development and disease but also propose a potential oncogenic function for Ubc13 and Uev1a, the mammalian homologs of Ben and dUev1a." @default.
- W1971461609 created "2016-06-24" @default.
- W1971461609 creator A5019690834 @default.
- W1971461609 creator A5049390055 @default.
- W1971461609 creator A5049704953 @default.
- W1971461609 creator A5054481476 @default.
- W1971461609 creator A5078649940 @default.
- W1971461609 creator A5084858290 @default.
- W1971461609 date "2013-10-17" @default.
- W1971461609 modified "2023-10-16" @default.
- W1971461609 title "Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila" @default.
- W1971461609 cites W1506505530 @default.
- W1971461609 cites W1967192173 @default.
- W1971461609 cites W1967582843 @default.
- W1971461609 cites W1970005842 @default.
- W1971461609 cites W1972082267 @default.
- W1971461609 cites W1972911812 @default.
- W1971461609 cites W1983035539 @default.
- W1971461609 cites W1990915902 @default.
- W1971461609 cites W1992418538 @default.
- W1971461609 cites W1996137175 @default.
- W1971461609 cites W1999274348 @default.
- W1971461609 cites W2003769148 @default.
- W1971461609 cites W2009315366 @default.
- W1971461609 cites W2021326140 @default.
- W1971461609 cites W2036988959 @default.
- W1971461609 cites W2039964495 @default.
- W1971461609 cites W2046010877 @default.
- W1971461609 cites W2047195990 @default.
- W1971461609 cites W2050925712 @default.
- W1971461609 cites W2056433467 @default.
- W1971461609 cites W2061413060 @default.
- W1971461609 cites W2064260286 @default.
- W1971461609 cites W2068167759 @default.
- W1971461609 cites W2071532423 @default.
- W1971461609 cites W2074561761 @default.
- W1971461609 cites W2085423858 @default.
- W1971461609 cites W2089599227 @default.
- W1971461609 cites W2101257013 @default.
- W1971461609 cites W2115799179 @default.
- W1971461609 cites W2119162687 @default.
- W1971461609 cites W2128278532 @default.
- W1971461609 cites W2136166556 @default.
- W1971461609 cites W2146298345 @default.
- W1971461609 cites W2154073936 @default.
- W1971461609 cites W2155255760 @default.
- W1971461609 cites W2156329968 @default.
- W1971461609 cites W2156552281 @default.
- W1971461609 cites W2163093080 @default.
- W1971461609 cites W2165200432 @default.
- W1971461609 cites W2165948908 @default.
- W1971461609 cites W2168915088 @default.
- W1971461609 cites W2171572099 @default.
- W1971461609 cites W2173390200 @default.
- W1971461609 cites W2320035559 @default.
- W1971461609 cites W2343043204 @default.
- W1971461609 cites W4243541841 @default.
- W1971461609 cites W4256258598 @default.
- W1971461609 doi "https://doi.org/10.1038/cddis.2013.392" @default.
- W1971461609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3920939" @default.
- W1971461609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24136228" @default.
- W1971461609 hasPublicationYear "2013" @default.
- W1971461609 type Work @default.
- W1971461609 sameAs 1971461609 @default.
- W1971461609 citedByCount "49" @default.
- W1971461609 countsByYear W19714616092014 @default.
- W1971461609 countsByYear W19714616092015 @default.
- W1971461609 countsByYear W19714616092016 @default.
- W1971461609 countsByYear W19714616092017 @default.
- W1971461609 countsByYear W19714616092018 @default.
- W1971461609 countsByYear W19714616092019 @default.
- W1971461609 countsByYear W19714616092020 @default.
- W1971461609 countsByYear W19714616092021 @default.
- W1971461609 countsByYear W19714616092022 @default.
- W1971461609 countsByYear W19714616092023 @default.
- W1971461609 crossrefType "journal-article" @default.
- W1971461609 hasAuthorship W1971461609A5019690834 @default.
- W1971461609 hasAuthorship W1971461609A5049390055 @default.
- W1971461609 hasAuthorship W1971461609A5049704953 @default.
- W1971461609 hasAuthorship W1971461609A5054481476 @default.
- W1971461609 hasAuthorship W1971461609A5078649940 @default.
- W1971461609 hasAuthorship W1971461609A5084858290 @default.
- W1971461609 hasBestOaLocation W19714616091 @default.
- W1971461609 hasConcept C104317684 @default.
- W1971461609 hasConcept C108636557 @default.
- W1971461609 hasConcept C127716648 @default.
- W1971461609 hasConcept C137738243 @default.
- W1971461609 hasConcept C1491633281 @default.
- W1971461609 hasConcept C190283241 @default.
- W1971461609 hasConcept C207177822 @default.
- W1971461609 hasConcept C31573885 @default.
- W1971461609 hasConcept C49353375 @default.
- W1971461609 hasConcept C54355233 @default.
- W1971461609 hasConcept C62112901 @default.
- W1971461609 hasConcept C62478195 @default.
- W1971461609 hasConcept C86803240 @default.
- W1971461609 hasConcept C95444343 @default.
- W1971461609 hasConcept C97037327 @default.