FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971478718> ?p ?o ?g. }

• W1971478718 endingPage "98" @default.
• W1971478718 startingPage "81" @default.
• W1971478718 abstract "The guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), also referred to as GC-A, is a single polypeptide molecule having a critical function in blood pressure regulation and cardiovascular homeostasis. GC-A/NPRA, which resides in the plasma membrane, consists of an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular cytoplasmic region containing a protein kinase-like homology domain (KHD) and a guanylyl cyclase (GC) catalytic domain. After binding with atrial and brain natriuretic peptides (ANP and BNP), GC-A/NPRA is internalized and sequestered into intracellular compartments. Therefore, GC-A/NPRA is a dynamic cellular macromolecule that traverses different subcellular compartments through its lifetime. This review describes the roles of short-signal sequences in the internalization, trafficking, and intracellular redistribution of GC-A/NPRA from cell surface to cell interior. Evidence indicates that, after internalization, the ligand–receptor complexes dissociate inside the cell and a population of GC-A/NPRA recycles back to the plasma membrane. Subsequently, the disassociated ligands are degraded in the lysosomes. However, a small percentage of the ligand escapes the lysosomal degradative pathway, and is released intact into culture medium. Using pharmacologic and molecular perturbants, emphasis has been placed on the cellular regulation and processing of ligand-bound GC-A/NPRA in terms of receptor trafficking and down-regulation in intact cells. The discussion is concluded by examining the functions of short-signal sequence motifs in the cellular life-cycle of GC-A/NPRA, including endocytosis, trafficking, metabolic processing, inactivation, and/or down-regulation in model cell systems." @default.
• W1971478718 created "2016-06-24" @default.
• W1971478718 creator A5013084644 @default.
• W1971478718 date "2009-11-26" @default.
• W1971478718 modified "2023-09-27" @default.
• W1971478718 title "Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif" @default.
• W1971478718 cites W1522096759 @default.
• W1971478718 cites W1525728123 @default.
• W1971478718 cites W1854447234 @default.
• W1971478718 cites W1905627889 @default.
• W1971478718 cites W1964194790 @default.
• W1971478718 cites W1966724300 @default.
• W1971478718 cites W1968573434 @default.
• W1971478718 cites W1969557235 @default.
• W1971478718 cites W1969677127 @default.
• W1971478718 cites W1972616722 @default.
• W1971478718 cites W1973286153 @default.
• W1971478718 cites W1975382404 @default.
• W1971478718 cites W1980445909 @default.
• W1971478718 cites W1981284040 @default.
• W1971478718 cites W1983094993 @default.
• W1971478718 cites W1983509986 @default.
• W1971478718 cites W1984893737 @default.
• W1971478718 cites W1986529810 @default.
• W1971478718 cites W1989352995 @default.
• W1971478718 cites W1990075625 @default.
• W1971478718 cites W1992894005 @default.
• W1971478718 cites W1996199957 @default.
• W1971478718 cites W1996409230 @default.
• W1971478718 cites W1997272952 @default.
• W1971478718 cites W1997409050 @default.
• W1971478718 cites W1997779855 @default.
• W1971478718 cites W1998139028 @default.
• W1971478718 cites W1998866496 @default.
• W1971478718 cites W1999156595 @default.
• W1971478718 cites W2002498826 @default.
• W1971478718 cites W2002527015 @default.
• W1971478718 cites W2003235464 @default.
• W1971478718 cites W2003309225 @default.
• W1971478718 cites W2004801897 @default.
• W1971478718 cites W2005982860 @default.
• W1971478718 cites W2006156983 @default.
• W1971478718 cites W2007090401 @default.
• W1971478718 cites W2009166071 @default.
• W1971478718 cites W2009778241 @default.
• W1971478718 cites W2009788934 @default.
• W1971478718 cites W2010730039 @default.
• W1971478718 cites W2013239918 @default.
• W1971478718 cites W2014431983 @default.
• W1971478718 cites W2017119979 @default.
• W1971478718 cites W2018541556 @default.
• W1971478718 cites W2019592403 @default.
• W1971478718 cites W2020642480 @default.
• W1971478718 cites W2021147060 @default.
• W1971478718 cites W2022842129 @default.
• W1971478718 cites W2028484500 @default.
• W1971478718 cites W2030093555 @default.
• W1971478718 cites W2030117227 @default.
• W1971478718 cites W2030458176 @default.
• W1971478718 cites W2030712051 @default.
• W1971478718 cites W2030891974 @default.
• W1971478718 cites W2034152941 @default.
• W1971478718 cites W2035026318 @default.
• W1971478718 cites W2036329205 @default.
• W1971478718 cites W2037403334 @default.
• W1971478718 cites W2039388418 @default.
• W1971478718 cites W2039885825 @default.
• W1971478718 cites W2039982472 @default.
• W1971478718 cites W2040111890 @default.
• W1971478718 cites W2043463661 @default.
• W1971478718 cites W2044343226 @default.
• W1971478718 cites W2044813579 @default.
• W1971478718 cites W2045016821 @default.
• W1971478718 cites W2045076976 @default.
• W1971478718 cites W2045333932 @default.
• W1971478718 cites W2046710673 @default.
• W1971478718 cites W2048159264 @default.
• W1971478718 cites W2049832880 @default.
• W1971478718 cites W2049883622 @default.
• W1971478718 cites W2050649115 @default.
• W1971478718 cites W2050960932 @default.
• W1971478718 cites W2051798982 @default.
• W1971478718 cites W2052097767 @default.
• W1971478718 cites W2053998186 @default.
• W1971478718 cites W2057681541 @default.
• W1971478718 cites W2059031237 @default.
• W1971478718 cites W2059048654 @default.
• W1971478718 cites W2060295319 @default.
• W1971478718 cites W2061671663 @default.
• W1971478718 cites W2063328825 @default.
• W1971478718 cites W2064365475 @default.
• W1971478718 cites W2064625798 @default.
• W1971478718 cites W2066282501 @default.
• W1971478718 cites W2067005574 @default.
• W1971478718 cites W2067196589 @default.
• W1971478718 cites W2067691363 @default.
• W1971478718 cites W2068489515 @default.
• W1971478718 cites W2068693331 @default.

• next