Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971488476> ?p ?o ?g. }
- W1971488476 endingPage "153" @default.
- W1971488476 startingPage "145" @default.
- W1971488476 abstract "Although the “cancer stem cell (CSC)” hypothesis was first proposed roughly 50 years ago, recent progress in stem cell biology and technologies has successfully achieved the identification of CSCs in a variety of cancers. CSCs are defined as a minor population which possesses a prominent ability to generate new tumors that faithfully reproduce the phenotype of original tumors in xenotransplant assays. Additionally, CSCs are able to self-renew and generate differentiated progenies to organize a hierarchical cell system in a similar fashion to normal stem cells. Although not all types of cancer follow the CSC theory, it provides an attractive cellular mechanism to account for the therapeutic resistance and recurrence of the disease. A minor population with CSC properties has been detected in a number of established hepatocellular carcinoma (HCC) cell lines and extensive analyses characterizing the CSC system in primary HCC samples are now ongoing. Considering that HCC has high rates of recurrence and mortality, novel therapeutic approaches are urgently required. Although the clinical relevance of CSCs remains elusive, deep understanding of the cellular organization of HCC may allow us to develop therapies targeting specific cell types such as CSCs." @default.
- W1971488476 created "2016-06-24" @default.
- W1971488476 creator A5029593209 @default.
- W1971488476 creator A5035221784 @default.
- W1971488476 creator A5042700054 @default.
- W1971488476 creator A5066227014 @default.
- W1971488476 date "2009-12-01" @default.
- W1971488476 modified "2023-10-01" @default.
- W1971488476 title "Cancer stem cells in hepatocellular carcinoma: Recent progress and perspective" @default.
- W1971488476 cites W1470296049 @default.
- W1971488476 cites W1963494649 @default.
- W1971488476 cites W1974532695 @default.
- W1971488476 cites W1976183817 @default.
- W1971488476 cites W1977836335 @default.
- W1971488476 cites W1978747495 @default.
- W1971488476 cites W1979421565 @default.
- W1971488476 cites W1979694132 @default.
- W1971488476 cites W1980429197 @default.
- W1971488476 cites W1980878904 @default.
- W1971488476 cites W1982786429 @default.
- W1971488476 cites W1983641075 @default.
- W1971488476 cites W1984927780 @default.
- W1971488476 cites W1987925274 @default.
- W1971488476 cites W1990765314 @default.
- W1971488476 cites W1992676863 @default.
- W1971488476 cites W1993423043 @default.
- W1971488476 cites W1994374831 @default.
- W1971488476 cites W1998666537 @default.
- W1971488476 cites W1999356404 @default.
- W1971488476 cites W2000265567 @default.
- W1971488476 cites W2007978249 @default.
- W1971488476 cites W2009143053 @default.
- W1971488476 cites W2010317454 @default.
- W1971488476 cites W2010653264 @default.
- W1971488476 cites W2013315155 @default.
- W1971488476 cites W2017200989 @default.
- W1971488476 cites W2018629625 @default.
- W1971488476 cites W2023316892 @default.
- W1971488476 cites W2023427658 @default.
- W1971488476 cites W2025571463 @default.
- W1971488476 cites W2026211487 @default.
- W1971488476 cites W2028497270 @default.
- W1971488476 cites W2029469189 @default.
- W1971488476 cites W2033120556 @default.
- W1971488476 cites W2033364737 @default.
- W1971488476 cites W2033928771 @default.
- W1971488476 cites W2034979953 @default.
- W1971488476 cites W2037902063 @default.
- W1971488476 cites W2038747312 @default.
- W1971488476 cites W2039767026 @default.
- W1971488476 cites W2050419281 @default.
- W1971488476 cites W2051055358 @default.
- W1971488476 cites W2051935450 @default.
- W1971488476 cites W2054657650 @default.
- W1971488476 cites W2058093430 @default.
- W1971488476 cites W2059880136 @default.
- W1971488476 cites W2060551076 @default.
- W1971488476 cites W2060893815 @default.
- W1971488476 cites W2062010380 @default.
- W1971488476 cites W2062759109 @default.
- W1971488476 cites W2067723951 @default.
- W1971488476 cites W2069785796 @default.
- W1971488476 cites W2071534620 @default.
- W1971488476 cites W2077841029 @default.
- W1971488476 cites W2079518314 @default.
- W1971488476 cites W2080366818 @default.
- W1971488476 cites W2080838269 @default.
- W1971488476 cites W2083479805 @default.
- W1971488476 cites W2084446191 @default.
- W1971488476 cites W2090513410 @default.
- W1971488476 cites W2090800257 @default.
- W1971488476 cites W2091291743 @default.
- W1971488476 cites W2094735859 @default.
- W1971488476 cites W2102085111 @default.
- W1971488476 cites W2104666893 @default.
- W1971488476 cites W2107320516 @default.
- W1971488476 cites W2112246274 @default.
- W1971488476 cites W2120845130 @default.
- W1971488476 cites W2121054813 @default.
- W1971488476 cites W2123128269 @default.
- W1971488476 cites W2124471593 @default.
- W1971488476 cites W2129922015 @default.
- W1971488476 cites W2130976070 @default.
- W1971488476 cites W2137672147 @default.
- W1971488476 cites W2140121036 @default.
- W1971488476 cites W2140254135 @default.
- W1971488476 cites W2142291307 @default.
- W1971488476 cites W2143995836 @default.
- W1971488476 cites W2146680438 @default.
- W1971488476 cites W2149226545 @default.
- W1971488476 cites W2152387543 @default.
- W1971488476 cites W2155507705 @default.
- W1971488476 cites W2158362968 @default.
- W1971488476 cites W2166805191 @default.
- W1971488476 cites W2167190072 @default.
- W1971488476 cites W2167960944 @default.
- W1971488476 cites W2168472139 @default.
- W1971488476 cites W2170845559 @default.