Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971493646> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1971493646 endingPage "17" @default.
- W1971493646 startingPage "12" @default.
- W1971493646 abstract "Hematopoietic stem cells (HSCs) give rise to variety of hematopoietic cells, and are responsible for blood production throughout adult life. Recent studies have demonstrated the potential of HSCs to produce various nonhematopoietic cells. Amplification of HSCs represents a potentially powerful approach not only to the treatment of various blood disorders but also to applying gene therapy or to regenerative medicine. Lnk is an adaptor protein consisting of PH, SH2 domains, and a C-terminal tyrosine phosphorylation site. Marked expansion of Blineage cells occurs in lnk-/- mice, indicating Lnk regulates B cell production by negatively controlling growth signals through c-Kit in B cell precursors. Lnk is also expressed in hematopoietic progenitors, and the number and the hematopoietic ability of HSCs are significantly increased in the absence of Lnk. While augmented signaling through c-Kit partly contributed to the increased progenitor cells in lnk-/- mice, it is likely that there exist Lnkdependent but c-Kit-independent signaling pathways whose absence leads to augmented ability of lnk-/- HSCs. These indicate that Lnk plays critical roles in the expansion and function of HSCs and provide useful clues for the amplification of HSCs and progenitor cells." @default.
- W1971493646 created "2016-06-24" @default.
- W1971493646 creator A5027642382 @default.
- W1971493646 date "2003-01-01" @default.
- W1971493646 modified "2023-10-18" @default.
- W1971493646 title "Lnk, a novel adaptor protein that negatively regulates expansion and hematopoietic ability of hematopoietic stem cells." @default.
- W1971493646 cites W1804861156 @default.
- W1971493646 cites W1908810890 @default.
- W1971493646 cites W1932148910 @default.
- W1971493646 cites W1983255429 @default.
- W1971493646 cites W1988976227 @default.
- W1971493646 cites W2025146835 @default.
- W1971493646 cites W2047240921 @default.
- W1971493646 cites W2067222394 @default.
- W1971493646 cites W2069556423 @default.
- W1971493646 cites W2083289299 @default.
- W1971493646 cites W2085371283 @default.
- W1971493646 cites W2113674401 @default.
- W1971493646 cites W2127173897 @default.
- W1971493646 cites W2132012375 @default.
- W1971493646 cites W2140619590 @default.
- W1971493646 cites W2316182158 @default.
- W1971493646 cites W2326925476 @default.
- W1971493646 cites W2335669842 @default.
- W1971493646 doi "https://doi.org/10.2492/jsir.23.12" @default.
- W1971493646 hasPublicationYear "2003" @default.
- W1971493646 type Work @default.
- W1971493646 sameAs 1971493646 @default.
- W1971493646 citedByCount "0" @default.
- W1971493646 crossrefType "journal-article" @default.
- W1971493646 hasAuthorship W1971493646A5027642382 @default.
- W1971493646 hasBestOaLocation W19714936461 @default.
- W1971493646 hasConcept C109159458 @default.
- W1971493646 hasConcept C183786373 @default.
- W1971493646 hasConcept C201750760 @default.
- W1971493646 hasConcept C2778086970 @default.
- W1971493646 hasConcept C28328180 @default.
- W1971493646 hasConcept C502942594 @default.
- W1971493646 hasConcept C62478195 @default.
- W1971493646 hasConcept C86803240 @default.
- W1971493646 hasConcept C95444343 @default.
- W1971493646 hasConceptScore W1971493646C109159458 @default.
- W1971493646 hasConceptScore W1971493646C183786373 @default.
- W1971493646 hasConceptScore W1971493646C201750760 @default.
- W1971493646 hasConceptScore W1971493646C2778086970 @default.
- W1971493646 hasConceptScore W1971493646C28328180 @default.
- W1971493646 hasConceptScore W1971493646C502942594 @default.
- W1971493646 hasConceptScore W1971493646C62478195 @default.
- W1971493646 hasConceptScore W1971493646C86803240 @default.
- W1971493646 hasConceptScore W1971493646C95444343 @default.
- W1971493646 hasIssue "1" @default.
- W1971493646 hasLocation W19714936461 @default.
- W1971493646 hasOpenAccess W1971493646 @default.
- W1971493646 hasPrimaryLocation W19714936461 @default.
- W1971493646 hasRelatedWork W1967114867 @default.
- W1971493646 hasRelatedWork W1996916774 @default.
- W1971493646 hasRelatedWork W2099977590 @default.
- W1971493646 hasRelatedWork W2118006608 @default.
- W1971493646 hasRelatedWork W2120223845 @default.
- W1971493646 hasRelatedWork W2121709505 @default.
- W1971493646 hasRelatedWork W2335878673 @default.
- W1971493646 hasRelatedWork W2920927997 @default.
- W1971493646 hasRelatedWork W2969249814 @default.
- W1971493646 hasRelatedWork W3182217228 @default.
- W1971493646 hasVolume "23" @default.
- W1971493646 isParatext "false" @default.
- W1971493646 isRetracted "false" @default.
- W1971493646 magId "1971493646" @default.
- W1971493646 workType "article" @default.