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- W1971497890 abstract "COMPARISON OF HISTOPATHOLOGICAL CHANGES IN ATRIAL AND VENTRICULAR SPECIMENS FROM DOGS WITH DILATED CARDIOMYOPATHY I. Janus*, A. Noszczyk-Nowak y, M. Nowak*, M. KandeferGola*, R. Ciaputa*, D. Poradowski z, U. Pas1awska y and J.A. Madej* *Department of Pathology, Division of Pathomorphology and Veterinary Forensics, yDepartment of Internal Medicine and Clinics of Diseases of Horses, Dogs and Cats and zDepartment of Biochemistry, Pharmacology and Toxicology, Division of Pharmacology and Toxicology, University of Environmental and Life Sciences, Wroclaw, Poland Introduction: Dilated cardiomyopathy (DCM) is a disease of both man and animals involving myocardial changes causing heart failure. The alterations are present mostly in the left ventricular wall, but may also involve the right ventricular wall and the interventricular septum. Materials and Methods: The study was carried out on a group of six dogs (four doberman pinchers and two boxers) with clinical evidence of dilated cardiomyopathy. Specimens from both atria, both ventricles and the interventricular septum were stained with HE and MassoneGoldner’s trichrome. The assessment of presence and intensity of fibrous tissue, adipose tissue, inflammatory infiltrates, vascular changes and cardiomyocyte degenerative changes was made. Results: Complex histological changes involving both atrial and ventricular walls were noted. There was more fibrous tissue in the atria compared with the ventricles, but no other significant differences were found. Conclusions: Previous work has indicated that histopathological changes can be found not only in the left, but also in the right ventricle. We compared specimens from all heart chambers, showing that alterations also affect the atrial myocardium. The observed higher intensity of fibrous tissue in atria compared with ventricles may reflect the high susceptibility of dogs with DCM to supraventricular rhythm disturbances. At this point it is impossible to specify whether the alterations are an effect of myocardial cell primary remodelling or a cardiac response to progressive overload and heart failure." @default.
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- W1971497890 date "2015-01-01" @default.
- W1971497890 modified "2023-09-23" @default.
- W1971497890 title "Comparison of histopathological changes in atrial and ventricular specimens from dogs with dilated cardiomyopathy" @default.
- W1971497890 doi "https://doi.org/10.1016/j.jcpa.2014.10.128" @default.
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