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• W1971499865 abstract "Blue light is known for its anti-microbial, anti-proliferative and anti-inflammatory effects. Furthermore, it is already usedfor the treatment of neonatal jaundice and acne. However, little is known about the exact mechanisms of action on geneexpression level.The aim of this study was to assess the impact of blue LED irradiation on the proliferation and gene expression inimmortalized human keratinocytes (HaCaT) in vitro. Furthermore its safety was assessed.XTT-tests revealed a decrease in cell proliferation in blue light irradiated cells depending on the duration of lightirradiation. Moreover, gene expression analysis demonstrated deregulated genes already 3 hours after blue lightirradiation. 24 hours after blue light irradiation the effects seemed to be even more pronounced. The oxidative stressresponse was significantly increased, pointing to increased ROS production due to blue light, as well as steroid hormonebiosynthesis. Downregulated pathways or biological processes were connected to anti-inflammatory response.Interestingly, also the melanoma pathway contained significantly downregulated genes 24 hours after blue lightirradiation, which stands in accordance to literature that blue light can also inhibit proliferation in cancer cells. First testswith melanoma cells revealed a decrease in cell proliferation after blue light irradiation. In conclusion, blue lightirradiation might open avenues to new therapeutic regimens; at least blue light seems to have no effect that inducescancer growth or formation." @default.
• W1971499865 created "2016-06-24" @default.
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• W1971499865 date "2015-03-05" @default.
• W1971499865 modified "2023-10-12" @default.
• W1971499865 title "Impact of blue LED irradiation on proliferation and gene expression of cultured human keratinocytes" @default.
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• W1971499865 doi "https://doi.org/10.1117/12.2083010" @default.
• W1971499865 hasPublicationYear "2015" @default.
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