Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971502127> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1971502127 endingPage "7135" @default.
- W1971502127 startingPage "7129" @default.
- W1971502127 abstract "Background: In this study, we aimed to evaluate the growth inhibitory effect of the combination of ethaselen (BBSKE) and low fixed dose of selenite against A549 human non-small cell lung cancer cells in vitro. Materials and Methods: Growth inhibitory effects against A549 cells were determined by SRB assay. Combination index (CI) values were calculated based on Chou-Talalay median-effect analyses. Dose reduction index (DRI) values were applied to calculate dose reduction of selenite. Contents of free thiols and GSH were determined by DTNB assay and intracellular ROS levels by DCFH-DA fluorescence labeling. Results: Compared with BBSKE or selenite single treatment, the combined application of ethaselen and a low fixed dose of selenite shortened the onset time of sodium selenite, reduced <TEX>$IC_{50}$</TEX> values, and increased the maximum inhibition rates, suggesting a possible molecular mechanism of the synergism. Obvious synergistic effects were observed after different times of combination treatment, especially after 24 h. Compared with selenite single treatment, dosage of selenite could be remarkably reduced in combination therapy to gain the same inhibitory effect on cell proliferation. Compared with BBSKE single treatment, the content of free thiols and GSH were significantly reduced and ROS levels greatly elevated in the combination group. For the combination treatment, cell viability increased as greater concentrations of GSH were added. Conclusions: All these results indicate that the combination treatment of BBSKE and selenite showed synergism to inhibit A549 cell proliferation in vitro, and also reduced the selenite dosage to mitigate its toxicity which is very meaningful for combination chemotherapy of lung cancer. The synergism was probably caused by the accelerated exhaustion of intracellular reductive substances, such as free thiols and GSH, which ultimately leads to enhanced oxidative stress and apoptosis." @default.
- W1971502127 created "2016-06-24" @default.
- W1971502127 creator A5060353579 @default.
- W1971502127 creator A5069923589 @default.
- W1971502127 creator A5087757550 @default.
- W1971502127 date "2014-09-15" @default.
- W1971502127 modified "2023-10-12" @default.
- W1971502127 title "Synergistic Effect of Ethaselen and Selenite Treatment against A549 Human Non-small Cell Lung Cancer Cells" @default.
- W1971502127 cites W1982043075 @default.
- W1971502127 cites W1982236221 @default.
- W1971502127 cites W2021816119 @default.
- W1971502127 cites W2027542963 @default.
- W1971502127 cites W2052597368 @default.
- W1971502127 cites W2053528495 @default.
- W1971502127 cites W2070291783 @default.
- W1971502127 cites W2080913348 @default.
- W1971502127 cites W2087343327 @default.
- W1971502127 cites W2096100878 @default.
- W1971502127 cites W2096439168 @default.
- W1971502127 cites W2120484980 @default.
- W1971502127 cites W2145085259 @default.
- W1971502127 cites W2170340134 @default.
- W1971502127 doi "https://doi.org/10.7314/apjcp.2014.15.17.7129" @default.
- W1971502127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25227802" @default.
- W1971502127 hasPublicationYear "2014" @default.
- W1971502127 type Work @default.
- W1971502127 sameAs 1971502127 @default.
- W1971502127 citedByCount "10" @default.
- W1971502127 countsByYear W19715021272015 @default.
- W1971502127 countsByYear W19715021272016 @default.
- W1971502127 countsByYear W19715021272017 @default.
- W1971502127 countsByYear W19715021272019 @default.
- W1971502127 countsByYear W19715021272020 @default.
- W1971502127 countsByYear W19715021272023 @default.
- W1971502127 crossrefType "journal-article" @default.
- W1971502127 hasAuthorship W1971502127A5060353579 @default.
- W1971502127 hasAuthorship W1971502127A5069923589 @default.
- W1971502127 hasAuthorship W1971502127A5087757550 @default.
- W1971502127 hasBestOaLocation W19715021271 @default.
- W1971502127 hasConcept C178790620 @default.
- W1971502127 hasConcept C181199279 @default.
- W1971502127 hasConcept C185592680 @default.
- W1971502127 hasConcept C202751555 @default.
- W1971502127 hasConcept C2777752497 @default.
- W1971502127 hasConcept C2780783641 @default.
- W1971502127 hasConcept C29730261 @default.
- W1971502127 hasConcept C53227056 @default.
- W1971502127 hasConcept C538909803 @default.
- W1971502127 hasConcept C553756173 @default.
- W1971502127 hasConcept C55493867 @default.
- W1971502127 hasConcept C62112901 @default.
- W1971502127 hasConcept C79879829 @default.
- W1971502127 hasConcept C81729549 @default.
- W1971502127 hasConcept C86803240 @default.
- W1971502127 hasConcept C98274493 @default.
- W1971502127 hasConceptScore W1971502127C178790620 @default.
- W1971502127 hasConceptScore W1971502127C181199279 @default.
- W1971502127 hasConceptScore W1971502127C185592680 @default.
- W1971502127 hasConceptScore W1971502127C202751555 @default.
- W1971502127 hasConceptScore W1971502127C2777752497 @default.
- W1971502127 hasConceptScore W1971502127C2780783641 @default.
- W1971502127 hasConceptScore W1971502127C29730261 @default.
- W1971502127 hasConceptScore W1971502127C53227056 @default.
- W1971502127 hasConceptScore W1971502127C538909803 @default.
- W1971502127 hasConceptScore W1971502127C553756173 @default.
- W1971502127 hasConceptScore W1971502127C55493867 @default.
- W1971502127 hasConceptScore W1971502127C62112901 @default.
- W1971502127 hasConceptScore W1971502127C79879829 @default.
- W1971502127 hasConceptScore W1971502127C81729549 @default.
- W1971502127 hasConceptScore W1971502127C86803240 @default.
- W1971502127 hasConceptScore W1971502127C98274493 @default.
- W1971502127 hasIssue "17" @default.
- W1971502127 hasLocation W19715021271 @default.
- W1971502127 hasLocation W19715021272 @default.
- W1971502127 hasOpenAccess W1971502127 @default.
- W1971502127 hasPrimaryLocation W19715021271 @default.
- W1971502127 hasRelatedWork W1994790143 @default.
- W1971502127 hasRelatedWork W2030996473 @default.
- W1971502127 hasRelatedWork W2050726565 @default.
- W1971502127 hasRelatedWork W2080323841 @default.
- W1971502127 hasRelatedWork W2125759595 @default.
- W1971502127 hasRelatedWork W2132152194 @default.
- W1971502127 hasRelatedWork W2166139349 @default.
- W1971502127 hasRelatedWork W2372999700 @default.
- W1971502127 hasRelatedWork W2749518884 @default.
- W1971502127 hasRelatedWork W894643644 @default.
- W1971502127 hasVolume "15" @default.
- W1971502127 isParatext "false" @default.
- W1971502127 isRetracted "false" @default.
- W1971502127 magId "1971502127" @default.
- W1971502127 workType "article" @default.