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- W1971508103 endingPage "11975" @default.
- W1971508103 startingPage "11963" @default.
- W1971508103 abstract "The ortho functionalization of methyl R-phenylglycinate has been easily achieved using the known orthopalladated complex [Pd(μ-Cl){R-C6H4(CH(CO2Me)NH2)-2}]2 (1) as synthetic tool. Different functional groups have been introduced at the ortho position of the aryl ring. The reaction of (R)-1 with X2 or PhI(OAc)2 gives XC6H4(CH(CO2Me)NH2)-2 (X = I, Br, OMe, OEt) through oxidative coupling, while the reaction with CO gives an isoindolone. (R)-1 also reacts with one, two, or three alkyne molecules to give different metal-containing or metal-free heterocycles. The resulting functionalized amino esters or heterocycles retain the chirality of (R)-1, according with the values of the optical rotation and the obtained ee values ranging from 22%−87%. The X-ray structures of six representative compounds have also been determined." @default.
- W1971508103 created "2016-06-24" @default.
- W1971508103 creator A5024529120 @default.
- W1971508103 creator A5024815988 @default.
- W1971508103 creator A5056829532 @default.
- W1971508103 creator A5056988969 @default.
- W1971508103 creator A5058748323 @default.
- W1971508103 creator A5081932543 @default.
- W1971508103 creator A5083225216 @default.
- W1971508103 date "2009-11-13" @default.
- W1971508103 modified "2023-09-30" @default.
- W1971508103 title "Functionalization of Methyl (<i>R</i>)-Phenylglycinate Through Orthopalladation: C−Hal, C−O, C−N, and C−C Bond Coupling" @default.
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