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- W1971509842 abstract "Objective: To estimate in-hospital, 1-yr, and long-term mortality and to assess time trends in incidence and outcomes of sepsis admissions in the intensive care unit. Design: A population-based, multicenter, retrospective cohort study. Patients: Patients hospitalized with sepsis in the intensive care unit in seven general hospitals in Israel during 2002–2008. Interventions: None. Measurements: Survival data were collected and analyzed according to demographic and background clinical characteristics, as well as features of the sepsis episode, using Kaplan-Meier approach for long-term survival. Main Results: A total of 5,155 patients were included in the cohort (median age: 70, 56.3% males; median Charlson comorbidity index: 4). The mean number of intensive care unit admissions per month increased over time, while no change in in-hospital mortality was observed. The proportion of patients surviving to hospital discharge was 43.9%. The 1-, 2-, 5-, and 8-yr survival rates were 33.0%, 29.8%, 23.3%, and 19.8%, respectively. Mortality was higher in older patients, patients with a higher Charlson comorbidity index, and those with multiorgan failure, and similar in males and females. One-year age-standardized mortality ratio was 21-fold higher than expected, based on the general population rates. Conclusions: Mortality following intensive care unit sepsis admission remains high and is correlated with underlying patients' characteristics, including age, comorbidities, and the number of failing organ systems." @default.
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- W1971509842 date "2012-03-01" @default.
- W1971509842 modified "2023-09-26" @default.
- W1971509842 title "Temporal trends in patient characteristics and survival of intensive care admissions with sepsis" @default.
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- W1971509842 doi "https://doi.org/10.1097/ccm.0b013e318236f7b8" @default.
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