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• W1971534487 abstract "<h3>Objective:</h3> To determine the utility of measuring the tumor proliferation index as a prognostic marker in patients with non—small-cell lung cancer. <h3>Design:</h3> Immunostaining for the proliferationassociated antigen Ki-67, quantitated using computerassisted image cytometry, was used to derive the tumor proliferation index for 61 fresh-frozen, banked specimens of non—small-cell lung cancer. DNA ploidy was measured concomitantly for all specimens. A median follow-up of 38 months was achieved for survival analyses. <h3>Setting:</h3> A large southeastern United States private referral institution and affiliated hospital provided the study environment. <h3>Participants:</h3> A consecutive, convenience sample of 61 patients was enrolled based on resected tissue preservation and viability over a five-year accruement. <h3>Main Outcome Measures:</h3> Significant associations between DNA content, proliferation index, established clinicopathological parameters, and outcome were examined. <h3>Results:</h3> A significant inverse association between patient survival and tumor proliferation index was found that was independent of other established clinicopathological predictors of outcome. Patients whose tumors harbored a proliferation index of less than 3.5 survived significantly longer than patients with tumors demonstrating higher values. No association between DNA content and proliferation index was uncovered. <h3>Conclusion:</h3> Measurement of the proliferation index, as derived from quantitative Ki-67 immunostaining and analyzed by image cytometry, may provide significant complementary, if not independent, prognostic information for patients with non—small-cell lung cancer. (Arch Surg. 1993;128:1382-1390)" @default.
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• W1971534487 date "1993-12-01" @default.
• W1971534487 modified "2023-10-18" @default.
• W1971534487 title "Prognostic Significance of the Proliferation Index in Surgically Resected Non—Small-Cell Lung Cancer" @default.
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• W1971534487 doi "https://doi.org/10.1001/archsurg.1993.01420240090017" @default.
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