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• W1971540502 endingPage "e53898" @default.
• W1971540502 startingPage "e53898" @default.
• W1971540502 abstract "The metabolism of potato (Solanum tuberosum) roots constitutively over- and underexpressing hexokinase (HK, EC 2.7.1.1) was examined. An 11-fold variation in HK activity resulted in altered root growth, with antisense roots growing better than sense roots. Quantification of sugars, organic acids and amino acids in transgenic roots demonstrated that the manipulation of HK activity had very little effect on the intracellular pools of these metabolites. However, adenylate and free Pi levels were negatively affected by an increase in HK activity. The flux control coefficient of HK over the phosphorylation of glucose was measured for the first time in plants. Its value varied with HK level. It reached 1.71 at or below normal HK activity value and was much lower (0.32) at very high HK levels. Measurements of glycolytic flux and O2 uptake rates demonstrated that the differences in glucose phosphorylation did not affect significantly glycolytic and respiratory metabolism. We hypothesized that these results could be explained by the existence of a futile cycle between the pools of hexose-Ps and carbohydrates. This view is supported by several lines of evidence. Firstly, activities of enzymes capable of catalyzing these reactions were detected in roots, including a hexose-P phosphatase. Secondly, metabolic tracer experiments using 14C-glucose as precursor showed the formation of 14C-fructose and 14C-sucrose. We conclude that futile cycling of hexose-P could be partially responsible for the differences in energetic status in roots with high and low HK activity and possibly cause the observed alterations in growth in transgenic roots. The involvement of HK and futile cycles in the control of glucose-6P metabolism is discussed." @default.
• W1971540502 created "2016-06-24" @default.
• W1971540502 creator A5007524667 @default.
• W1971540502 creator A5007717721 @default.
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• W1971540502 creator A5017627109 @default.
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• W1971540502 creator A5067269870 @default.
• W1971540502 creator A5073515965 @default.
• W1971540502 creator A5085365697 @default.
• W1971540502 date "2013-01-28" @default.
• W1971540502 modified "2023-10-16" @default.
• W1971540502 title "The Futile Cycling of Hexose Phosphates Could Account for the Fact That Hexokinase Exerts a High Control on Glucose Phosphorylation but Not on Glycolytic Rate in Transgenic Potato (Solanum tuberosum) Roots" @default.
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• W1971540502 doi "https://doi.org/10.1371/journal.pone.0053898" @default.

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