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• W1971542014 abstract "Mucoepidermoid carcinoma (MEC) is a relatively uncommon carcinoma of variable histology that can involve many tissue types, most commonly major and minor salivary glands and the tracheo-bronchial tree. In a significant number of cases a recurring t(11;19) translocation with an associated novel fusion oncogene (CRTC1-MAML2) is present. This translocation is also found in Warthin's tumour and clear cell hidradenoma of the skin. The CRTC1-MAML2 oncogene acts as a transcription factor on Notch and CREB regulatory pathways, disrupting normal cell-cycle and differentiation, contributing to tumour development. Data suggest that in MEC, the presence of CRTC1-MAML2 may have some prognostic value. An understanding of these mechanisms extends our knowledge of the role of fusion oncogenes in epithelial malignancy. A review of CRTC1-MAML2 in MEC is presented." @default.
• W1971542014 created "2016-06-24" @default.
• W1971542014 creator A5052503649 @default.
• W1971542014 date "2009-01-01" @default.
• W1971542014 modified "2023-10-02" @default.
• W1971542014 title "t(11;19) translocation and CRTC1-MAML2 fusion oncogene in mucoepidermoid carcinoma" @default.
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• W1971542014 doi "https://doi.org/10.1016/j.oraloncology.2008.03.012" @default.
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