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• W1971542511 abstract "To explore the rate of reported congenital abnormalities in infants exposed to antiretroviral therapy in utero.Comprehensive national surveillance study in the UK and Ireland.Births to diagnosed HIV-infected women are reported to the National Study of HIV in Pregnancy and Childhood. Infants born between 1990 and 2007 were included.The rate of reported major and minor congenital abnormality was 2.8% (232/8242) overall, and there was no significant difference by timing of ART exposure: 2.8% (14/498) in unexposed infants, 2.7% (147/5427) following second or third trimester exposure, and 3.1% (53/1708) following first trimester exposure (P = 0.690). There was no difference in abnormality rates by class of ART exposure in the first trimester (P = 0.363), and no category of abnormality was significantly associated with timing of ART, although numbers in these groups were small. There was no increased risk of abnormalities in infants exposed to efavirenz (P = 0.672) or didanosine (P = 0.816) in the first trimester.These findings, based on a large, national, unselected population provide further reassurance that ART in utero does not pose a major risk of fetal anomaly." @default.
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• W1971542511 date "2009-02-20" @default.
• W1971542511 modified "2023-10-07" @default.
• W1971542511 title "Antiretroviral therapy and congenital abnormalities in infants born to HIV-infected women in the UK and Ireland, 1990–2007" @default.
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• W1971542511 doi "https://doi.org/10.1097/qad.0b013e328326ca8e" @default.
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