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• W1971545938 abstract "A novel phenotypic anti-human immunodeficiency virus type 1 (HIV-1) drug resistance assay is described. Three drugs at concentrations equivalent to those determined in in vivo pharmacokinetics, were mixed in a well, serially diluted by 10-folds, and added to incubations of clinical HIV-1 isolates and CCR-5 expressing HeLa/CD4+ cells which was previously reported as the MAGIC-5 cells (Antimicrob. Agents Chemother. 45 (2001) 495) to determine the 95% inhibitory dilution (ID(95)) of the combination regimens. The ID(95) of efavirenz (EFV)-containing regimens was ten-times lower than that of nevirapine (NVP)-containing regimens against HIV-1 isolated from antiviral therapy naive patients. However, the difference was not apparent by the conventional fold resistance measurement based on the 50% inhibitory concentration. Furthermore, the synergistic effects of drug combinations against clinical HIV-1 isolates can be evaluated by our assay. The ID(95)s of EFV- and nelfinavir (NFV)- containing regimens against HIV-1 from naive patients were less than 0.01 whereas those against resistant viruses were over 0.05, although the clinical cut-off values are to be determined in larger clinical studies. Our assay, designated All-in-One Assay, that can examine resistance to three drugs simultaneously under consideration of in vivo drug concentrations described above might be useful in practice." @default.
• W1971545938 created "2016-06-24" @default.
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• W1971545938 date "2003-07-01" @default.
• W1971545938 modified "2023-10-18" @default.
• W1971545938 title "“All-in-One Assay”, a direct phenotypic anti-human immunodeficiency virus type 1 drug resistance assay for three-drug combination therapies that takes into consideration in vivo drug concentrations" @default.
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• W1971545938 doi "https://doi.org/10.1016/s0166-0934(03)00150-2" @default.
• W1971545938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12821196" @default.
• W1971545938 hasPublicationYear "2003" @default.
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