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- W1971556688 abstract "Purpose: The authors present a stochastic framework for the assessment of cell survival in gold nanoparticle radiotherapy. Methods: The authors derive the equations for the effective macroscopic dose enhancement for a population of cells with nonideal distribution of gold nanoparticles (GNP), allowing different number of GNP per cell and different distances with respect to the cellular target. They use the mixed Poisson distribution formalism to model the impact of the aforementioned physical factors on the effective dose enhancement. Results: The authors show relatively large differences in the estimation of cell survival arising from using approximated formulae. They predict degeneration of the cell killing capacity due to different number of GNP per cell and different distances with respect to the cellular target. Conclusions: The presented stochastic framework can be used in interpretation of experimental cell survival or tumor control probability studies." @default.
- W1971556688 created "2016-06-24" @default.
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- W1971556688 date "2013-01-14" @default.
- W1971556688 modified "2023-10-16" @default.
- W1971556688 title "A stochastic model of cell survival for high-Z nanoparticle radiotherapy" @default.
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- W1971556688 doi "https://doi.org/10.1118/1.4773885" @default.
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