Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971566688> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1971566688 endingPage "290" @default.
- W1971566688 startingPage "283" @default.
- W1971566688 abstract "Although the presence of anti-mitochondrial antibodies is the main characteristic of primary biliary cirrhosis (PBC), other autoantibodies have been described in this disease. This study employs immunoblot methods to test whether the sera of PBC patients also contain antibodies directed against nicotinic acetylcholine receptors (AChR). We show that the majority of patients' sera indeed react with AChR just as sera of myasthenic patients do. In contrast, however, these anti-AChR antibodies do not lead to significant clinical symptoms of myasthenia. In all cases studied, PBC sera recognized a protein with the molecular weight of the α-chain of acetylcholine receptor (40 kDa). In addition, with both liver mitochondria and AChR-rich membranes as antigens, PBC sera reacted with proteins with apparent molecular weights around 68 kDa and the same pI values. This protein is not present in purified AChR preparations. These data suggest structural, if not functional, relationships between membrane components of liver mitochondria and muscle endplates. Although the presence of anti-mitochondrial antibodies is the main characteristic of primary biliary cirrhosis (PBC), other autoantibodies have been described in this disease. This study employs immunoblot methods to test whether the sera of PBC patients also contain antibodies directed against nicotinic acetylcholine receptors (AChR). We show that the majority of patients' sera indeed react with AChR just as sera of myasthenic patients do. In contrast, however, these anti-AChR antibodies do not lead to significant clinical symptoms of myasthenia. In all cases studied, PBC sera recognized a protein with the molecular weight of the α-chain of acetylcholine receptor (40 kDa). In addition, with both liver mitochondria and AChR-rich membranes as antigens, PBC sera reacted with proteins with apparent molecular weights around 68 kDa and the same pI values. This protein is not present in purified AChR preparations. These data suggest structural, if not functional, relationships between membrane components of liver mitochondria and muscle endplates." @default.
- W1971566688 created "2016-06-24" @default.
- W1971566688 creator A5002523311 @default.
- W1971566688 creator A5018899274 @default.
- W1971566688 creator A5043117792 @default.
- W1971566688 creator A5064529740 @default.
- W1971566688 creator A5067911784 @default.
- W1971566688 creator A5074867425 @default.
- W1971566688 creator A5078491617 @default.
- W1971566688 creator A5087707424 @default.
- W1971566688 date "1988-01-01" @default.
- W1971566688 modified "2023-10-02" @default.
- W1971566688 title "Immunochemical characterization of anti-acetylcholine receptor antibodies in primary biliary cirrhosis" @default.
- W1971566688 cites W1583381215 @default.
- W1971566688 cites W1606423922 @default.
- W1971566688 cites W1664613266 @default.
- W1971566688 cites W1964825359 @default.
- W1971566688 cites W1965142345 @default.
- W1971566688 cites W1974399445 @default.
- W1971566688 cites W1983732198 @default.
- W1971566688 cites W2000579563 @default.
- W1971566688 cites W2012315029 @default.
- W1971566688 cites W2040109772 @default.
- W1971566688 cites W2083269122 @default.
- W1971566688 cites W2100837269 @default.
- W1971566688 cites W2914120646 @default.
- W1971566688 cites W4239173340 @default.
- W1971566688 doi "https://doi.org/10.1016/s0168-8278(88)80044-8" @default.
- W1971566688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3292637" @default.
- W1971566688 hasPublicationYear "1988" @default.
- W1971566688 type Work @default.
- W1971566688 sameAs 1971566688 @default.
- W1971566688 citedByCount "21" @default.
- W1971566688 countsByYear W19715666882012 @default.
- W1971566688 countsByYear W19715666882016 @default.
- W1971566688 countsByYear W19715666882017 @default.
- W1971566688 countsByYear W19715666882020 @default.
- W1971566688 countsByYear W19715666882022 @default.
- W1971566688 countsByYear W19715666882023 @default.
- W1971566688 crossrefType "journal-article" @default.
- W1971566688 hasAuthorship W1971566688A5002523311 @default.
- W1971566688 hasAuthorship W1971566688A5018899274 @default.
- W1971566688 hasAuthorship W1971566688A5043117792 @default.
- W1971566688 hasAuthorship W1971566688A5064529740 @default.
- W1971566688 hasAuthorship W1971566688A5067911784 @default.
- W1971566688 hasAuthorship W1971566688A5074867425 @default.
- W1971566688 hasAuthorship W1971566688A5078491617 @default.
- W1971566688 hasAuthorship W1971566688A5087707424 @default.
- W1971566688 hasConcept C147483822 @default.
- W1971566688 hasConcept C159654299 @default.
- W1971566688 hasConcept C163764329 @default.
- W1971566688 hasConcept C170493617 @default.
- W1971566688 hasConcept C185592680 @default.
- W1971566688 hasConcept C188987157 @default.
- W1971566688 hasConcept C203014093 @default.
- W1971566688 hasConcept C2778105408 @default.
- W1971566688 hasConcept C2779075594 @default.
- W1971566688 hasConcept C2780366471 @default.
- W1971566688 hasConcept C2994419564 @default.
- W1971566688 hasConcept C55493867 @default.
- W1971566688 hasConcept C71924100 @default.
- W1971566688 hasConcept C80161118 @default.
- W1971566688 hasConcept C86803240 @default.
- W1971566688 hasConceptScore W1971566688C147483822 @default.
- W1971566688 hasConceptScore W1971566688C159654299 @default.
- W1971566688 hasConceptScore W1971566688C163764329 @default.
- W1971566688 hasConceptScore W1971566688C170493617 @default.
- W1971566688 hasConceptScore W1971566688C185592680 @default.
- W1971566688 hasConceptScore W1971566688C188987157 @default.
- W1971566688 hasConceptScore W1971566688C203014093 @default.
- W1971566688 hasConceptScore W1971566688C2778105408 @default.
- W1971566688 hasConceptScore W1971566688C2779075594 @default.
- W1971566688 hasConceptScore W1971566688C2780366471 @default.
- W1971566688 hasConceptScore W1971566688C2994419564 @default.
- W1971566688 hasConceptScore W1971566688C55493867 @default.
- W1971566688 hasConceptScore W1971566688C71924100 @default.
- W1971566688 hasConceptScore W1971566688C80161118 @default.
- W1971566688 hasConceptScore W1971566688C86803240 @default.
- W1971566688 hasIssue "3" @default.
- W1971566688 hasLocation W19715666881 @default.
- W1971566688 hasLocation W19715666882 @default.
- W1971566688 hasOpenAccess W1971566688 @default.
- W1971566688 hasPrimaryLocation W19715666881 @default.
- W1971566688 hasRelatedWork W1968860695 @default.
- W1971566688 hasRelatedWork W1971566688 @default.
- W1971566688 hasRelatedWork W1972081278 @default.
- W1971566688 hasRelatedWork W2059155026 @default.
- W1971566688 hasRelatedWork W2079728170 @default.
- W1971566688 hasRelatedWork W2156431312 @default.
- W1971566688 hasRelatedWork W2229503226 @default.
- W1971566688 hasRelatedWork W2462185525 @default.
- W1971566688 hasRelatedWork W3032291227 @default.
- W1971566688 hasRelatedWork W4379769286 @default.
- W1971566688 hasVolume "6" @default.
- W1971566688 isParatext "false" @default.
- W1971566688 isRetracted "false" @default.
- W1971566688 magId "1971566688" @default.
- W1971566688 workType "article" @default.