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• W1971569479 abstract "In the infertile male population, there is a 2–20-time higher probability of having a structural chromosomal abnormality than in general population. Generally, these men have a normal phenotype but they can have sperm abnormalities. As they can produce a variable proportion of unbalanced gametes, it is important to evaluate the percentage of unbalanced chromosomal spermatozoa to assess the risk of injecting a chromosomally unbalanced gamete during ICSI procedure. We report here the meiotic segregation analysis of chromosomes in spermatozoa of 12 men with a balanced reciprocal translocation and 4 men with a Robertsonian translocation using a fluorescent in situ hybridisation analysis. The frequencies of normal or balanced spermatozoa ranged from 34.4% to 49.1% in balanced reciprocal translocation carriers. For Robertsonian translocation, the frequencies of normal or balanced spermatozoa ranged from 78.4% to 91.2%. These analyses allow us to define the orientation of genetic counselling according to the results of meiotic segregation obtained. As a last resort, it could then be discussed of the possibility of having recourse to donor spermatozoa or adoption." @default.
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• W1971569479 date "2010-02-01" @default.
• W1971569479 modified "2023-10-14" @default.
• W1971569479 title "A study of meiotic segregation of chromosomes in spermatozoa of translocation carriers using fluorescent<i>in situ</i>hybridisation" @default.
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• W1971569479 doi "https://doi.org/10.1111/j.1439-0272.2009.00951.x" @default.
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