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- W1971570984 abstract "The profiles of lipid peroxidation products in liver homogenates or microsomal membranes prepared from CCl 4 -intoxicated mice were determined by several commonly employed methods. The level of conjugated dienes peaked within 30 min and then decreased, suggesting the transitory nature of lipid peroxides in vivo. Values for thiobarbituric acid positive material peaked 30 min after CCl 4 treatment, diminished thereafter for a time, and gradually rose to a new maximum at 24 h; the first peak appears to represent lipid peroxides and the second represents further degradation products including malondialdehyde. Fluorescence intensity (excitation, 360 nm; emission, 430 nm) was closely correlated with the second peak. Our findings support the involvement of lipid peroxidation in CCl 4 -induced hepatotoxicity in mice and emphasize the necessity for several analytical indices of lipid peroxidation performed at different time intervals." @default.
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- W1971570984 date "1987-07-01" @default.
- W1971570984 modified "2023-09-26" @default.
- W1971570984 title "Criteria for determination of lipid peroxidation in tissues: estimation in liver of mice intoxicated with carbon tetrachloride" @default.
- W1971570984 doi "https://doi.org/10.1139/y87-236" @default.
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