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- W1971578051 abstract "A possible participation of polyphosphoinositide metabolism in the excitation‐contraction coupling in heart was investigated. Isolated rat ventricles prelabelled with myo ‐[2‐ 3 H]inositol were stimulated by conditions that increase mechanical activity. Both noradrenaline and carbachol increased the basal level of IP 3 IP 2 and IP by the activation of α 1 ‐adrenergic and muscarinic receptors, respectively. Electrical stimulation accelerated inositol lipid degradation by phospholipase C thus enhancing the IP 3 level as compared to quiescent ventricles. It is proposed that IP 3 may be involved in excitation‐contraction coupling in cardiac tissue." @default.
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- W1971578051 title "Inositol phosphate production following α<sub>1</sub> -adrenergic, muscarinic or electrical stimulation in isolated rat heart" @default.
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- W1971578051 doi "https://doi.org/10.1016/0014-5793(86)80999-1" @default.
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