Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971591577> ?p ?o ?g. }
- W1971591577 endingPage "56" @default.
- W1971591577 startingPage "42" @default.
- W1971591577 abstract "The cholinergic neuronal system, through its projections to the hippocampus, plays an important role in learning and memory. The aim of the study was to identify genes and networks in rat hippocampus with and without memory deficit. Genome-scale screening was used to analyze gene expression changes in rats submitted or not to intraparenchymal injection of 192 IgG-saporin and trained in spatial/object novelty tasks. Results showed learning processes were associated with significant expression of genes that could be grouped into several clusters of similar expression profiles and that are involved in biological functions, namely lipid metabolism, signal transduction, protein metabolism and modification, and transcription regulation. Memory loss following hippocampal cholinergic deafferentation was associated with significant expression of genes that did not show similar cluster organization. Only one cluster of genes could be identified; it included genes that would be involved in tissue remodeling. More important, most of the genes significantly altered in lesioned rats were down-regulated." @default.
- W1971591577 created "2016-06-24" @default.
- W1971591577 creator A5014567598 @default.
- W1971591577 creator A5020569095 @default.
- W1971591577 creator A5030337077 @default.
- W1971591577 creator A5038290834 @default.
- W1971591577 creator A5082453760 @default.
- W1971591577 date "2010-07-01" @default.
- W1971591577 modified "2023-10-17" @default.
- W1971591577 title "Gene expression profile in rat hippocampus with and without memory deficit" @default.
- W1971591577 cites W1528914253 @default.
- W1971591577 cites W1960607431 @default.
- W1971591577 cites W1972419595 @default.
- W1971591577 cites W1976396449 @default.
- W1971591577 cites W1976540475 @default.
- W1971591577 cites W1983412249 @default.
- W1971591577 cites W1984498194 @default.
- W1971591577 cites W1986262058 @default.
- W1971591577 cites W1986737010 @default.
- W1971591577 cites W1986815429 @default.
- W1971591577 cites W1989964812 @default.
- W1971591577 cites W1990060970 @default.
- W1971591577 cites W1992206604 @default.
- W1971591577 cites W1994067502 @default.
- W1971591577 cites W1996900261 @default.
- W1971591577 cites W1998902445 @default.
- W1971591577 cites W2000757153 @default.
- W1971591577 cites W2001226357 @default.
- W1971591577 cites W2004899864 @default.
- W1971591577 cites W2005805321 @default.
- W1971591577 cites W2008681970 @default.
- W1971591577 cites W2011379230 @default.
- W1971591577 cites W2015272601 @default.
- W1971591577 cites W2015373793 @default.
- W1971591577 cites W2015956155 @default.
- W1971591577 cites W2016107968 @default.
- W1971591577 cites W2018434736 @default.
- W1971591577 cites W2018843440 @default.
- W1971591577 cites W2021155777 @default.
- W1971591577 cites W2021954046 @default.
- W1971591577 cites W2022388123 @default.
- W1971591577 cites W2024722910 @default.
- W1971591577 cites W2029626898 @default.
- W1971591577 cites W2035051064 @default.
- W1971591577 cites W2037554926 @default.
- W1971591577 cites W2039954108 @default.
- W1971591577 cites W2042956033 @default.
- W1971591577 cites W2046611929 @default.
- W1971591577 cites W2049293055 @default.
- W1971591577 cites W2056312358 @default.
- W1971591577 cites W2061403265 @default.
- W1971591577 cites W2061670886 @default.
- W1971591577 cites W2061733344 @default.
- W1971591577 cites W2063350061 @default.
- W1971591577 cites W2063445979 @default.
- W1971591577 cites W2066297165 @default.
- W1971591577 cites W2069776467 @default.
- W1971591577 cites W2069862324 @default.
- W1971591577 cites W2075799258 @default.
- W1971591577 cites W2076261565 @default.
- W1971591577 cites W2082720729 @default.
- W1971591577 cites W2091395024 @default.
- W1971591577 cites W2094012319 @default.
- W1971591577 cites W2098425296 @default.
- W1971591577 cites W2112090702 @default.
- W1971591577 cites W2117071406 @default.
- W1971591577 cites W2119270366 @default.
- W1971591577 cites W2127150445 @default.
- W1971591577 cites W2132977458 @default.
- W1971591577 cites W2139084975 @default.
- W1971591577 cites W2145025818 @default.
- W1971591577 cites W2158223072 @default.
- W1971591577 cites W2161141468 @default.
- W1971591577 cites W2161639176 @default.
- W1971591577 cites W2163500926 @default.
- W1971591577 cites W2170989872 @default.
- W1971591577 cites W2335362962 @default.
- W1971591577 cites W3100378500 @default.
- W1971591577 cites W4232833871 @default.
- W1971591577 cites W58071118 @default.
- W1971591577 doi "https://doi.org/10.1016/j.nlm.2010.03.005" @default.
- W1971591577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20359541" @default.
- W1971591577 hasPublicationYear "2010" @default.
- W1971591577 type Work @default.
- W1971591577 sameAs 1971591577 @default.
- W1971591577 citedByCount "10" @default.
- W1971591577 countsByYear W19715915772012 @default.
- W1971591577 countsByYear W19715915772017 @default.
- W1971591577 countsByYear W19715915772018 @default.
- W1971591577 countsByYear W19715915772019 @default.
- W1971591577 countsByYear W19715915772020 @default.
- W1971591577 countsByYear W19715915772023 @default.
- W1971591577 crossrefType "journal-article" @default.
- W1971591577 hasAuthorship W1971591577A5014567598 @default.
- W1971591577 hasAuthorship W1971591577A5020569095 @default.
- W1971591577 hasAuthorship W1971591577A5030337077 @default.
- W1971591577 hasAuthorship W1971591577A5038290834 @default.
- W1971591577 hasAuthorship W1971591577A5082453760 @default.