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- W1971595606 abstract "Abstract In tumorigenicity experiments, each animal begins in a tumor-free state and then either develops a tumor or dies before developing a tumor. Animals that develop a tumor either die from the tumor or from other competing causes. All surviving animals are sacrificed at the end of the experiment, normally two years. The two most commonly used statistical tests are the logrank test for comparing hazards of death from rapidly lethal tumors and the Hoel-Walburg test for comparing prevalences of nonlethal tumors. However, the data obtained from a carcinogenicity experiment generally contains a mixture of fatal and incidental tumors. Peto et al.(1980)suggested combining the fatal and incidental tests for a comparison of tumor onset distributions. Extensive simulations show that the trend test for tumor onset using the Peto procedure has the proper size, under the simulation constraints, when each group has identical mortality patterns, and the test with continuity correction tends to be conservative. When the animals n the dosed groups have reduced survival rates, the type I error rate is likely to exceed the nominal level. The continuity correction is recommended for a small reduction in survival time among the dosed groups to ensure the proper size. However, when there is a large reduction in survival times in the dosed groups, the onset test does not have the proper size. Keywords: Logrank testHoel-Walburg testPeto onset test" @default.
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- W1971595606 date "1994-01-01" @default.
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- W1971595606 title "Impact of surviving time on tests for carcinogenicity" @default.
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- W1971595606 doi "https://doi.org/10.1080/03610929408831328" @default.
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