Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971617059> ?p ?o ?g. }
- W1971617059 endingPage "414" @default.
- W1971617059 startingPage "406" @default.
- W1971617059 abstract "In this study we investigated the role of endothelin-1 (ET-1) and its peripheral receptor (ET-A) in carcinoma-induced pain in a mouse cancer pain model. Tumors were induced in the hind paw of female mice by local injection of cells derived from a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at four days after SCC inoculation and lasted to 28 days, the last day of measurement. Intra-tumor expression of both ET-1 mRNA and ET-1 protein were significantly upregulated compared to normal tissue, and local administration of the ET-A receptor selective antagonist, BQ-123 (100 microM) significantly elevated withdrawal thresholds, indicating the induction of an antinociceptive effect. These findings support the suggestion that ET-1 and ET-A receptors contribute to the severity of carcinoma-induced soft tissue cancer pain." @default.
- W1971617059 created "2016-06-24" @default.
- W1971617059 creator A5015358737 @default.
- W1971617059 creator A5015929707 @default.
- W1971617059 creator A5022523427 @default.
- W1971617059 creator A5035125245 @default.
- W1971617059 creator A5044937806 @default.
- W1971617059 creator A5065416384 @default.
- W1971617059 creator A5070079531 @default.
- W1971617059 date "2007-05-01" @default.
- W1971617059 modified "2023-09-26" @default.
- W1971617059 title "Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain" @default.
- W1971617059 cites W1566638862 @default.
- W1971617059 cites W1590661230 @default.
- W1971617059 cites W1592184520 @default.
- W1971617059 cites W1654216633 @default.
- W1971617059 cites W1969668711 @default.
- W1971617059 cites W1971289357 @default.
- W1971617059 cites W1976066038 @default.
- W1971617059 cites W1980762198 @default.
- W1971617059 cites W1988245823 @default.
- W1971617059 cites W1988450070 @default.
- W1971617059 cites W1993129895 @default.
- W1971617059 cites W1999563475 @default.
- W1971617059 cites W2001201925 @default.
- W1971617059 cites W2005204942 @default.
- W1971617059 cites W2009278812 @default.
- W1971617059 cites W2011527953 @default.
- W1971617059 cites W2012809928 @default.
- W1971617059 cites W2015691870 @default.
- W1971617059 cites W2021534784 @default.
- W1971617059 cites W2025605415 @default.
- W1971617059 cites W2036696609 @default.
- W1971617059 cites W2042465203 @default.
- W1971617059 cites W2042659981 @default.
- W1971617059 cites W2054605958 @default.
- W1971617059 cites W2060314283 @default.
- W1971617059 cites W2062425377 @default.
- W1971617059 cites W2066965763 @default.
- W1971617059 cites W2073160762 @default.
- W1971617059 cites W2076475433 @default.
- W1971617059 cites W2077483410 @default.
- W1971617059 cites W2079112648 @default.
- W1971617059 cites W2080319877 @default.
- W1971617059 cites W2089158347 @default.
- W1971617059 cites W2091490160 @default.
- W1971617059 cites W2103351070 @default.
- W1971617059 cites W2127461273 @default.
- W1971617059 cites W2155133695 @default.
- W1971617059 cites W2172201406 @default.
- W1971617059 cites W4237635696 @default.
- W1971617059 doi "https://doi.org/10.1016/j.ejpain.2006.05.007" @default.
- W1971617059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16807013" @default.
- W1971617059 hasPublicationYear "2007" @default.
- W1971617059 type Work @default.
- W1971617059 sameAs 1971617059 @default.
- W1971617059 citedByCount "58" @default.
- W1971617059 countsByYear W19716170592012 @default.
- W1971617059 countsByYear W19716170592013 @default.
- W1971617059 countsByYear W19716170592014 @default.
- W1971617059 countsByYear W19716170592015 @default.
- W1971617059 countsByYear W19716170592016 @default.
- W1971617059 countsByYear W19716170592017 @default.
- W1971617059 countsByYear W19716170592018 @default.
- W1971617059 countsByYear W19716170592019 @default.
- W1971617059 countsByYear W19716170592020 @default.
- W1971617059 countsByYear W19716170592021 @default.
- W1971617059 countsByYear W19716170592022 @default.
- W1971617059 countsByYear W19716170592023 @default.
- W1971617059 crossrefType "journal-article" @default.
- W1971617059 hasAuthorship W1971617059A5015358737 @default.
- W1971617059 hasAuthorship W1971617059A5015929707 @default.
- W1971617059 hasAuthorship W1971617059A5022523427 @default.
- W1971617059 hasAuthorship W1971617059A5035125245 @default.
- W1971617059 hasAuthorship W1971617059A5044937806 @default.
- W1971617059 hasAuthorship W1971617059A5065416384 @default.
- W1971617059 hasAuthorship W1971617059A5070079531 @default.
- W1971617059 hasConcept C104317684 @default.
- W1971617059 hasConcept C121608353 @default.
- W1971617059 hasConcept C126322002 @default.
- W1971617059 hasConcept C127561419 @default.
- W1971617059 hasConcept C134018914 @default.
- W1971617059 hasConcept C144980905 @default.
- W1971617059 hasConcept C149601957 @default.
- W1971617059 hasConcept C15490471 @default.
- W1971617059 hasConcept C170493617 @default.
- W1971617059 hasConcept C185592680 @default.
- W1971617059 hasConcept C24998067 @default.
- W1971617059 hasConcept C2776885963 @default.
- W1971617059 hasConcept C2777546739 @default.
- W1971617059 hasConcept C2778122271 @default.
- W1971617059 hasConcept C46762472 @default.
- W1971617059 hasConcept C55493867 @default.
- W1971617059 hasConcept C71924100 @default.
- W1971617059 hasConceptScore W1971617059C104317684 @default.
- W1971617059 hasConceptScore W1971617059C121608353 @default.
- W1971617059 hasConceptScore W1971617059C126322002 @default.
- W1971617059 hasConceptScore W1971617059C127561419 @default.