FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971617706> ?p ?o ?g. }

• W1971617706 endingPage "154" @default.
• W1971617706 startingPage "139" @default.
• W1971617706 abstract "This report describes the isolation and characterization of a class of RNA polymerase (rifR) mutations in Escherichia coli strain C600 that retards the growth of bacteriophage λ. In a typical example of this class of mutants, strain C600 rifR-2, phage early functions (pN, pint, pxis, phage DNA replication, and phage early mRNA synthesis) are expressed normally. However, the expression of late phage functions (late mRNA synthesis, lysozyme synthesis, and virus production) is delayed in this host. Since the transcription of late λ genes depends partially on the prior synthesis of phage gene Q protein (pQ), this defect could reflect either an inability of pQ to work properly in the mutant host (activity model) or reduced pQ synthesis in this host (synthesis model). The synthesis model is supported by two results: (1) phage growth in the absence of pQ is also defective in the mutant host; and (2) phage mutations, nin5 and byp, which bypass the need for pN at transcription termination signal tR2 overcome the host defect. Thus, this defect must at least in part reflect a reduced ability of pN to allow transcription beyond termination signal tR2 into the Q gene. However, it cannot be ruled out that the rifR-2 mutation might also affect pQ activity. Since pN works normally in the mutant host to overcome transcription barriers at sites tR1 and tL, the host RNA polymerase mutation appears to affect the ability of pN to act at the various phage transcription termination signals differentially. A strain containing both the rifR-2 mutation and a second host mutation defective for phage pN activity, nusA-1 (Friedman et al., 1973a), has been constructed and is significantly more defective for phage growth than can be accounted for by the additive defects produced by both single mutations. This synergistic effect suggests that proper interaction between at least two host components (RNA polymerase and pnusA) and a phage component (pN) is essential for normal transcription of the λ genome." @default.
• W1971617706 created "2016-06-24" @default.
• W1971617706 creator A5016596435 @default.
• W1971617706 date "1976-08-01" @default.
• W1971617706 modified "2023-09-25" @default.
• W1971617706 title "A class of rifR RNA polymerase mutations that interferes with the expression of coliphage λ late genes" @default.
• W1971617706 cites W1481198043 @default.
• W1971617706 cites W1485287156 @default.
• W1971617706 cites W1487151281 @default.
• W1971617706 cites W1532579456 @default.
• W1971617706 cites W1535722856 @default.
• W1971617706 cites W1775749144 @default.
• W1971617706 cites W1971883502 @default.
• W1971617706 cites W1972873061 @default.
• W1971617706 cites W1975066681 @default.
• W1971617706 cites W1975170215 @default.
• W1971617706 cites W1980085210 @default.
• W1971617706 cites W1985649341 @default.
• W1971617706 cites W1986403340 @default.
• W1971617706 cites W1994619148 @default.
• W1971617706 cites W1995285448 @default.
• W1971617706 cites W2000556662 @default.
• W1971617706 cites W2004642793 @default.
• W1971617706 cites W2008036319 @default.
• W1971617706 cites W2014276467 @default.
• W1971617706 cites W2015363344 @default.
• W1971617706 cites W2030214861 @default.
• W1971617706 cites W2037493883 @default.
• W1971617706 cites W2042640406 @default.
• W1971617706 cites W2042919489 @default.
• W1971617706 cites W2047140320 @default.
• W1971617706 cites W2050599642 @default.
• W1971617706 cites W2052023868 @default.
• W1971617706 cites W2052750133 @default.
• W1971617706 cites W2055567598 @default.
• W1971617706 cites W2058094890 @default.
• W1971617706 cites W2067474270 @default.
• W1971617706 cites W2082487355 @default.
• W1971617706 cites W2088974713 @default.
• W1971617706 cites W2090932793 @default.
• W1971617706 cites W2093533123 @default.
• W1971617706 cites W2115476139 @default.
• W1971617706 cites W2134011061 @default.
• W1971617706 cites W2162042496 @default.
• W1971617706 cites W4246336260 @default.
• W1971617706 doi "https://doi.org/10.1016/0042-6822(76)90068-4" @default.
• W1971617706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/785804" @default.
• W1971617706 hasPublicationYear "1976" @default.
• W1971617706 type Work @default.
• W1971617706 sameAs 1971617706 @default.
• W1971617706 citedByCount "43" @default.
• W1971617706 crossrefType "journal-article" @default.
• W1971617706 hasAuthorship W1971617706A5016596435 @default.
• W1971617706 hasConcept C10079403 @default.
• W1971617706 hasConcept C104317684 @default.
• W1971617706 hasConcept C138885662 @default.
• W1971617706 hasConcept C143065580 @default.
• W1971617706 hasConcept C153911025 @default.
• W1971617706 hasConcept C179926584 @default.
• W1971617706 hasConcept C2776441376 @default.
• W1971617706 hasConcept C2776449523 @default.
• W1971617706 hasConcept C41895202 @default.
• W1971617706 hasConcept C54355233 @default.
• W1971617706 hasConcept C547475151 @default.
• W1971617706 hasConcept C67705224 @default.
• W1971617706 hasConcept C82381507 @default.
• W1971617706 hasConcept C86803240 @default.
• W1971617706 hasConceptScore W1971617706C10079403 @default.
• W1971617706 hasConceptScore W1971617706C104317684 @default.
• W1971617706 hasConceptScore W1971617706C138885662 @default.
• W1971617706 hasConceptScore W1971617706C143065580 @default.
• W1971617706 hasConceptScore W1971617706C153911025 @default.
• W1971617706 hasConceptScore W1971617706C179926584 @default.
• W1971617706 hasConceptScore W1971617706C2776441376 @default.
• W1971617706 hasConceptScore W1971617706C2776449523 @default.
• W1971617706 hasConceptScore W1971617706C41895202 @default.
• W1971617706 hasConceptScore W1971617706C54355233 @default.
• W1971617706 hasConceptScore W1971617706C547475151 @default.
• W1971617706 hasConceptScore W1971617706C67705224 @default.
• W1971617706 hasConceptScore W1971617706C82381507 @default.
• W1971617706 hasConceptScore W1971617706C86803240 @default.
• W1971617706 hasIssue "1" @default.
• W1971617706 hasLocation W19716177061 @default.
• W1971617706 hasLocation W19716177062 @default.
• W1971617706 hasOpenAccess W1971617706 @default.
• W1971617706 hasPrimaryLocation W19716177061 @default.
• W1971617706 hasRelatedWork W1488542966 @default.
• W1971617706 hasRelatedWork W1492171871 @default.
• W1971617706 hasRelatedWork W1585378712 @default.
• W1971617706 hasRelatedWork W1680469369 @default.
• W1971617706 hasRelatedWork W1981142562 @default.
• W1971617706 hasRelatedWork W2061659910 @default.
• W1971617706 hasRelatedWork W2092207057 @default.
• W1971617706 hasRelatedWork W2416446416 @default.
• W1971617706 hasRelatedWork W262780512 @default.
• W1971617706 hasRelatedWork W4323284755 @default.
• W1971617706 hasVolume "73" @default.
• W1971617706 isParatext "false" @default.

• next