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- W1971620531 abstract "Background: In bifurcations, 2-stent strategy is usually associated with higher restenosis rate than a 1-stent strategy (provisional stenting). Methods: 15 ovine coronary bifurcations received main vessel Cypher stents and then were allocated to group T (n 8; T-stenting of the side branch with Cypher) or group P (n 7; PTCA of the side branch). At 180 days, the proximal, carina and distal segments of the bifurcation underwent radiographic and histologic evaluation. Results: All morphometric and qualitative data were comparable between groups at the proximal and distal sections. At the carina section, group T showed a significantly greater degree of neointimal growth (5.06 1.42 mm2 versus 2.21 0.69 mm2, p 0.001) and percent area stenosis (51.4 13.3% versus 31.1 7.2%, p 0.004) compared with group P. Both inflammation score (1.14 0.48 versus 0.36 0.38, p 0.005) and fibrin deposition (14.66 8.17% versus 0.79 2.10%, p 0.001) were significantly higher in group T. Granulomas and giant cells were observed in group T but absent in group P. Stent fracture was more prevalent (87.5% vs. 28.6%, p 0.05) and severe (multiple fracture: 87.5% vs. 14.3%, p 0.01; major fracture: 62.5% vs. 0%, p 0.05) in group T than group P, mostly involving the connectors at the side branches. Neointimal eccentricity was insignificantly higher in group T than group P (0.94 0.06 versus 0.89 0.12, p 0.45). Conclusions: Compared with balloon angioplasty, side branch T-stenting induced more neointimal growth which was likely related to higher incidence of fractures, persistent inflammation and fibrin deposition." @default.
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- W1971620531 date "2012-10-01" @default.
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- W1971620531 title "TCT-686 T-stenting with Two Drug-Eluting Stents Versus One Drug-Eluting Stent with Side Branch PTCA: Long-Term Pathological Findings in Bifurcation Lesions" @default.
- W1971620531 doi "https://doi.org/10.1016/j.jacc.2012.08.724" @default.
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