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- W1971629792 abstract "Abstract This study was undertaken to elucidate the effects of maternal protein malnutrition on the matrix cell and the differentiation of neurons in the embryonic mouse cerebrum. Mothers fed a low protein diet from the 8th to the 16th day of gestation, carried 16-day-old embryos whose cerebral cortex width was reduced significantly; some of the matrix cells and migrating young neurons showed degeneration including necrosis in their ultrastructural morphology. However, when these pregnant mice were subsequently fed a normal diet from the 16th day of gestation to term, no significant changes from the controls in the width of the cortex and in ultrastructural morphology were found at birth. In contrast, mothers fed a low protein diet from the 13th day of gestation, delivered their embryos 1 day prior to term, i.e., on the 19th day of gestation. Thus, they were compared with the control fetuses of the 19th day of gestation. Their mean body weight was about 51% of that of age-matched controls and the width of their cerebral cortex was significantly smaller. Electron microscopic observation of the cytoplasm of neurons in layer II of their cerebral cortex contained more ribosomes than did the control specimens and neuronal processes in the intercellular space were decreased." @default.
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- W1971629792 date "1980-05-01" @default.
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- W1971629792 title "Effect of maternal protein malnutrition on the developing cerebral cortex of mouse embryo: An electron microscopic study" @default.
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- W1971629792 doi "https://doi.org/10.1016/0014-4886(80)90081-3" @default.
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