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• W1971638473 endingPage "771" @default.
• W1971638473 startingPage "766" @default.
• W1971638473 abstract "Systemic sclerosis, or scleroderma, is an uncommon autoimmune connective tissue disease that results in systemic fibrosis. Its etiologic basis remains unclear. The pathogenesis of systemic sclerosis involves a proliferative and obliterative vasculopathy resulting from endothelial cell dysfunction, extensive fibrosis secondary to fibroblast activation, and autoimmunity as demonstrated by the presence of disease-specific autoantibodies. Although there is no clear and convincing evidence for an environmental trigger in most cases, accumulating data emphasize the role of genetic factors in systemic sclerosis. As in other complex human diseases, multiple genes likely contribute to disease susceptibility and the clinical manifestations of systemic sclerosis. This review will cover the application of genomics to the complex genetics of systemic sclerosis.The following review is an update on novel targets identified in scleroderma based on published reports (May 2000-May 2003) of mutation/polymorphism analysis (using SNP and haplotyping), the results from a recent genome-wide scan on a Native American population with systemic sclerosis, and gene expression studies (microarrays).The use of genomics has revealed novel targets and genetic associations that may contribute to the cause, the onset, and the subsequent pathologic changes that constitute systemic sclerosis. The identification of potential candidates for gene therapy or disease-specific targets amenable to pharmacologic intervention will benefit patients with systemic sclerosis who are currently being treated for their symptoms and not the disease process itself." @default.
• W1971638473 created "2016-06-24" @default.
• W1971638473 creator A5046825874 @default.
• W1971638473 creator A5058607368 @default.
• W1971638473 date "2003-11-01" @default.
• W1971638473 modified "2023-10-18" @default.
• W1971638473 title "Identification of novel targets in scleroderma: update on population studies, cDNA arrays, SNP analysis, and mutations" @default.
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• W1971638473 doi "https://doi.org/10.1097/00002281-200311000-00014" @default.
• W1971638473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14569208" @default.
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