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• W1971645181 startingPage "6673" @default.
• W1971645181 abstract "Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the yeast Saccharomyces cerevisiae , are excellent models of asymmetric cell division, this phenotype occurs in all cell divisions; consequently, models of lineage-specific segregation patterns in these systems do not exist. Here, we report the first example of lineage-specific asymmetric division in yeast. We used fluorescent tags to show that components of the yeast kinetochore, the protein complex that anchors chromosomes to the mitotic spindle, divide asymmetrically in a single postmeiotic lineage. This phenotype is not seen in vegetatively dividing haploid or diploid cells. This kinetochore asymmetry suggests a mechanism for the selective segregation of sister centromeres to daughter cells to establish different cell lineages or fates. These results provide a mechanistic link between lineage-defining asymmetry of metazoa with unicellular eukaryotes." @default.
• W1971645181 created "2016-06-24" @default.
• W1971645181 creator A5008448460 @default.
• W1971645181 creator A5028622476 @default.
• W1971645181 creator A5069789373 @default.
• W1971645181 date "2009-04-21" @default.
• W1971645181 modified "2023-10-03" @default.
• W1971645181 title "Kinetochore asymmetry defines a single yeast lineage" @default.
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• W1971645181 doi "https://doi.org/10.1073/pnas.0811248106" @default.
• W1971645181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2672522" @default.
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• W1971645181 hasPublicationYear "2009" @default.
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