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• W1971648364 endingPage "212" @default.
• W1971648364 startingPage "205" @default.
• W1971648364 abstract "The specific, irreversible binding of [3H]β-funaltrexamine (β-FNA) to μ opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]β-FNA followed by a washing procedure with 1 μM unlabeled naltrexone in the washing medium. Regional distribution studies of the specific, irreversible binding of [3H]β-FNA revealed that slices of striatum and midbrain were richest in μ opioid receptors. Slices of cerebral cortex and medulla-pons had much lower amounts and the cerebellum had virtually no μ opioid receptors. Examination of the kinetics of the specific, irreversible binding of [3H]β-FNA revealed that although the maximum binding of β-FNA to striatal and midbrain slices of control and morphine tolerant/dependent mice did not differ, the rate at which β-FNA associated with the receptor was increased in the slices from morphine tolerant/dependent animals. The increase in association probably occurred at the initial recognition step before alkylation takes place and is attributable to an increase in affinity of μ opioid receptors for β-FNA in both the striatal and midbrain regions of morphine tolerant/dependent mice. This finding supports and expands earlier conclusions that the affinity of μ opioid receptors for opioid antagonists is increased during the development of opiate tolerance and dependence in mice." @default.
• W1971648364 created "2016-06-24" @default.
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• W1971648364 date "1988-05-01" @default.
• W1971648364 modified "2023-09-26" @default.
• W1971648364 title "Irreversible binding of [3H]β-funaltremaxine to brain slices of morphine-tolerant and -dependent mice" @default.
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• W1971648364 doi "https://doi.org/10.1016/0014-2999(88)90650-4" @default.
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• W1971648364 hasPublicationYear "1988" @default.
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