FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971657016> ?p ?o ?g. }

• W1971657016 endingPage "e100492" @default.
• W1971657016 startingPage "e100492" @default.
• W1971657016 abstract "Skin ulceration syndrome (SUS) is considered to be a major constraint for the stable development of Apostichopus japonicus culture industries. In this study, we investigated protein changes in the coelomocytes of A. japonicus challenged by Vibrio splendidus using isobaric tags for relative and absolute quantification (iTRAQ) over a 96 h time course. Consequently, 228 differentially expressed proteins were identified in two iTRAQs. A comparison of the protein expression profiles among different time points detected 125 proteins primarily involved in response to endogenous stimuli at 24 h. At 48 h, the number of differentially expressed proteins decreased to 67, with their primary function being oxidation reduction. At the end of pathogen infection, proteins responsive to amino acid stimuli and some metabolic processes were classified as the predominant group. Fifteen proteins were differentially expressed at all time points, among which eight proteins related to pathologies in higher animals were shown to be down-regulated after V. splendidus infection: paxillin, fascin-2, aggrecan, ololfactomedin-1, nesprin-3, a disintegrin-like and metallopeptidase with thrombospondin type 1 motif (Adamts7), C-type lectin domain family 4 (Clec4g) and n-myc downstream regulated gene 1 (Ndrg1). To gain more insight into two SUS-related miRNA (miR-31 and miR-2008) targets at the protein level, all 129 down-regulated proteins were further analyzed in combination with RNA-seq. Twelve and eight proteins were identified as putative targets for miR-31 and miR-2008, respectively, in which six proteins (5 for miR-31 and 1 for miR-2008) displayed higher possibilities to be regulated at the level of translation. Overall, the present work enhances our understanding of the process of V. splendidus-challenged sea cucumber and provides a new method for screening miRNAs targets at the translation level." @default.
• W1971657016 created "2016-06-24" @default.
• W1971657016 creator A5002930270 @default.
• W1971657016 creator A5030729366 @default.
• W1971657016 creator A5053762107 @default.
• W1971657016 creator A5054336938 @default.
• W1971657016 creator A5069198283 @default.
• W1971657016 creator A5085201377 @default.
• W1971657016 date "2014-06-20" @default.
• W1971657016 modified "2023-10-16" @default.
• W1971657016 title "iTRAQ-Based Proteomics Reveals Novel Members Involved in Pathogen Challenge in Sea Cucumber Apostichopus japonicus" @default.
• W1971657016 cites W14272306 @default.
• W1971657016 cites W144423133 @default.
• W1971657016 cites W1579500241 @default.
• W1971657016 cites W1967454801 @default.
• W1971657016 cites W1971388179 @default.
• W1971657016 cites W1980792029 @default.
• W1971657016 cites W1992221435 @default.
• W1971657016 cites W1998558137 @default.
• W1971657016 cites W2000200199 @default.
• W1971657016 cites W2001387260 @default.
• W1971657016 cites W2006581388 @default.
• W1971657016 cites W2011476001 @default.
• W1971657016 cites W2019102807 @default.
• W1971657016 cites W2036171395 @default.
• W1971657016 cites W2036253737 @default.
• W1971657016 cites W2045840366 @default.
• W1971657016 cites W2054080132 @default.
• W1971657016 cites W2059802440 @default.
• W1971657016 cites W2100491916 @default.
• W1971657016 cites W2115129497 @default.
• W1971657016 cites W2117391818 @default.
• W1971657016 cites W2120486068 @default.
• W1971657016 cites W2121424839 @default.
• W1971657016 cites W2124666089 @default.
• W1971657016 cites W2141547848 @default.
• W1971657016 cites W2144800232 @default.
• W1971657016 cites W2146138309 @default.
• W1971657016 cites W2161401556 @default.
• W1971657016 cites W2162212201 @default.
• W1971657016 cites W2170873880 @default.
• W1971657016 cites W3099017147 @default.
• W1971657016 cites W4293247451 @default.
• W1971657016 doi "https://doi.org/10.1371/journal.pone.0100492" @default.
• W1971657016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4065040" @default.
• W1971657016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24949634" @default.
• W1971657016 hasPublicationYear "2014" @default.
• W1971657016 type Work @default.
• W1971657016 sameAs 1971657016 @default.
• W1971657016 citedByCount "40" @default.
• W1971657016 countsByYear W19716570162013 @default.
• W1971657016 countsByYear W19716570162015 @default.
• W1971657016 countsByYear W19716570162016 @default.
• W1971657016 countsByYear W19716570162017 @default.
• W1971657016 countsByYear W19716570162018 @default.
• W1971657016 countsByYear W19716570162019 @default.
• W1971657016 countsByYear W19716570162020 @default.
• W1971657016 countsByYear W19716570162021 @default.
• W1971657016 countsByYear W19716570162023 @default.
• W1971657016 crossrefType "journal-article" @default.
• W1971657016 hasAuthorship W1971657016A5002930270 @default.
• W1971657016 hasAuthorship W1971657016A5030729366 @default.
• W1971657016 hasAuthorship W1971657016A5053762107 @default.
• W1971657016 hasAuthorship W1971657016A5054336938 @default.
• W1971657016 hasAuthorship W1971657016A5069198283 @default.
• W1971657016 hasAuthorship W1971657016A5085201377 @default.
• W1971657016 hasBestOaLocation W19716570161 @default.
• W1971657016 hasConcept C104317684 @default.
• W1971657016 hasConcept C129075420 @default.
• W1971657016 hasConcept C153911025 @default.
• W1971657016 hasConcept C167814343 @default.
• W1971657016 hasConcept C181199279 @default.
• W1971657016 hasConcept C18903297 @default.
• W1971657016 hasConcept C2776093933 @default.
• W1971657016 hasConcept C2777267774 @default.
• W1971657016 hasConcept C46111723 @default.
• W1971657016 hasConcept C55493867 @default.
• W1971657016 hasConcept C55728118 @default.
• W1971657016 hasConcept C80311884 @default.
• W1971657016 hasConcept C86803240 @default.
• W1971657016 hasConcept C95444343 @default.
• W1971657016 hasConceptScore W1971657016C104317684 @default.
• W1971657016 hasConceptScore W1971657016C129075420 @default.
• W1971657016 hasConceptScore W1971657016C153911025 @default.
• W1971657016 hasConceptScore W1971657016C167814343 @default.
• W1971657016 hasConceptScore W1971657016C181199279 @default.
• W1971657016 hasConceptScore W1971657016C18903297 @default.
• W1971657016 hasConceptScore W1971657016C2776093933 @default.
• W1971657016 hasConceptScore W1971657016C2777267774 @default.
• W1971657016 hasConceptScore W1971657016C46111723 @default.
• W1971657016 hasConceptScore W1971657016C55493867 @default.
• W1971657016 hasConceptScore W1971657016C55728118 @default.
• W1971657016 hasConceptScore W1971657016C80311884 @default.
• W1971657016 hasConceptScore W1971657016C86803240 @default.
• W1971657016 hasConceptScore W1971657016C95444343 @default.
• W1971657016 hasIssue "6" @default.
• W1971657016 hasLocation W19716570161 @default.
• W1971657016 hasLocation W19716570162 @default.

• next