FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971667637> ?p ?o ?g. }

• W1971667637 endingPage "202" @default.
• W1971667637 startingPage "192" @default.
• W1971667637 abstract "The Sry-related HMG box transcription factor, Sox17, is required for formation of definitive endoderm that gives rise to various organs, including thyroid, lung, liver, pancreas, and intestine. While expressed at high levels in the embryonic endoderm, Sox17 is also expressed in mature tissues, including the lung. Sox17 expression in respiratory epithelial cells was first detected in the fetal lung at embryonic day 18. Thereafter, Sox17 expression was restricted primarily to ciliated cells, suggesting its potential role in airway cell differentiation. When expressed in epithelial cells of the embryonic lung, Sox17 inhibited peripheral epithelial cell differentiation and disrupted branching morphogenesis. In vitro, Sox17 inhibited Sftpc and enhanced Foxj1 promoter activity, consistent with its expression in proximal airway cells. Conditional expression of Sox17 in peripheral respiratory epithelial cells of adult lung induced hyperplastic clusters of cells expressing increased levels of β-catenin and differentiation markers representing multiple proximal respiratory epithelial cell types. Sox17 prolonged survival and enhanced growth and differentiation of respiratory epithelial cells in vitro. Sox17 induced plasticity of respiratory epithelial cells, reprogramming alveolar cells into epithelial cells with characteristics more typical of the proximal airway. Sites of expression and the effects of Sox17 in vivo and in vitro are consistent with a role for Sox17 or other members of the Sox family of transcription factors in differentiation of the conducting airway epithelium." @default.
• W1971667637 created "2016-06-24" @default.
• W1971667637 creator A5001813162 @default.
• W1971667637 creator A5003793915 @default.
• W1971667637 creator A5037288031 @default.
• W1971667637 creator A5040126408 @default.
• W1971667637 creator A5075471637 @default.
• W1971667637 date "2006-06-01" @default.
• W1971667637 modified "2023-10-10" @default.
• W1971667637 title "Sox17 influences the differentiation of respiratory epithelial cells" @default.
• W1971667637 cites W1595812751 @default.
• W1971667637 cites W1648092828 @default.
• W1971667637 cites W1925655957 @default.
• W1971667637 cites W1982388659 @default.
• W1971667637 cites W1983371747 @default.
• W1971667637 cites W2008118174 @default.
• W1971667637 cites W2024925152 @default.
• W1971667637 cites W2024931422 @default.
• W1971667637 cites W2026566753 @default.
• W1971667637 cites W2026813670 @default.
• W1971667637 cites W2031683488 @default.
• W1971667637 cites W2035222904 @default.
• W1971667637 cites W2043861102 @default.
• W1971667637 cites W2049378557 @default.
• W1971667637 cites W2054924247 @default.
• W1971667637 cites W2056092000 @default.
• W1971667637 cites W2074978112 @default.
• W1971667637 cites W2077658669 @default.
• W1971667637 cites W2079181843 @default.
• W1971667637 cites W2080053495 @default.
• W1971667637 cites W2082155787 @default.
• W1971667637 cites W2086892504 @default.
• W1971667637 cites W2088519666 @default.
• W1971667637 cites W2091094858 @default.
• W1971667637 cites W2101027724 @default.
• W1971667637 cites W2103344845 @default.
• W1971667637 cites W2110510042 @default.
• W1971667637 cites W2129163745 @default.
• W1971667637 cites W2130752844 @default.
• W1971667637 cites W2131062818 @default.
• W1971667637 cites W2131959123 @default.
• W1971667637 cites W2137075665 @default.
• W1971667637 cites W2139419405 @default.
• W1971667637 cites W2143973293 @default.
• W1971667637 cites W2148086821 @default.
• W1971667637 cites W2156726032 @default.
• W1971667637 cites W2162186194 @default.
• W1971667637 cites W2166339788 @default.
• W1971667637 cites W2166364885 @default.
• W1971667637 cites W2169529166 @default.
• W1971667637 cites W2184947876 @default.
• W1971667637 cites W3040446784 @default.
• W1971667637 cites W35957379 @default.
• W1971667637 doi "https://doi.org/10.1016/j.ydbio.2006.02.038" @default.
• W1971667637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16574095" @default.
• W1971667637 hasPublicationYear "2006" @default.
• W1971667637 type Work @default.
• W1971667637 sameAs 1971667637 @default.
• W1971667637 citedByCount "69" @default.
• W1971667637 countsByYear W19716676372012 @default.
• W1971667637 countsByYear W19716676372013 @default.
• W1971667637 countsByYear W19716676372014 @default.
• W1971667637 countsByYear W19716676372015 @default.
• W1971667637 countsByYear W19716676372016 @default.
• W1971667637 countsByYear W19716676372017 @default.
• W1971667637 countsByYear W19716676372018 @default.
• W1971667637 countsByYear W19716676372019 @default.
• W1971667637 countsByYear W19716676372020 @default.
• W1971667637 countsByYear W19716676372021 @default.
• W1971667637 countsByYear W19716676372023 @default.
• W1971667637 crossrefType "journal-article" @default.
• W1971667637 hasAuthorship W1971667637A5001813162 @default.
• W1971667637 hasAuthorship W1971667637A5003793915 @default.
• W1971667637 hasAuthorship W1971667637A5037288031 @default.
• W1971667637 hasAuthorship W1971667637A5040126408 @default.
• W1971667637 hasAuthorship W1971667637A5075471637 @default.
• W1971667637 hasBestOaLocation W19716676371 @default.
• W1971667637 hasConcept C104317684 @default.
• W1971667637 hasConcept C105702510 @default.
• W1971667637 hasConcept C126322002 @default.
• W1971667637 hasConcept C145103041 @default.
• W1971667637 hasConcept C148738053 @default.
• W1971667637 hasConcept C203014093 @default.
• W1971667637 hasConcept C2777164004 @default.
• W1971667637 hasConcept C2777714996 @default.
• W1971667637 hasConcept C529295009 @default.
• W1971667637 hasConcept C534529494 @default.
• W1971667637 hasConcept C54355233 @default.
• W1971667637 hasConcept C55493867 @default.
• W1971667637 hasConcept C71924100 @default.
• W1971667637 hasConcept C86803240 @default.
• W1971667637 hasConcept C87568996 @default.
• W1971667637 hasConcept C95444343 @default.
• W1971667637 hasConceptScore W1971667637C104317684 @default.
• W1971667637 hasConceptScore W1971667637C105702510 @default.
• W1971667637 hasConceptScore W1971667637C126322002 @default.
• W1971667637 hasConceptScore W1971667637C145103041 @default.
• W1971667637 hasConceptScore W1971667637C148738053 @default.

• next