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• W1971674609 abstract "Wnt signaling pathway is essential for development and tumorigenesis, however, this signaling pathway in the progress of hepatocellular carcinoma (HCC) remains unclear. In this paper, we studied the function of human T-cell transcription factor-4 (TCF4), a key factor of Wnt signaling pathway, on the proliferation of HCC cell line. We showed that the expression of TCF4 mRNA in HCC cell line BEL-7402 was higher than that in immortalized normal liver cell line L02. Blockage of Wnt pathway by ΔNTCF4, a dominant negative TCF4, could suppress BEL-7402 cells growth and decrease the expression of cyclin D1 and c-myc, two of target genes of Wnt pathway. On the other hand, stimulating Wnt pathway by introducing a degradation-resistant β-catenin S37A could increase BEL-7402 cells proliferation. But all the treatments had no effect on L02 cells. Our data indicated that TCF4 might be another key factor in Wnt pathway involved in HCC cells proliferation and TCF4 could be an effective therapeutic target for suppressing the growth of hepatocellular cancers." @default.
• W1971674609 created "2016-06-24" @default.
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• W1971674609 date "2004-02-01" @default.
• W1971674609 modified "2023-10-08" @default.
• W1971674609 title "Aberrant expression and function of TCF4 in the proliferation of hepatocellular carcinoma cell line BEL-7402" @default.
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• W1971674609 doi "https://doi.org/10.1038/sj.cr.7290205" @default.
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