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• W1971679339 abstract "The voluntary preference for ethyl alcohol in Sprague-Dawlet rats was determined over 12 days with water as the alternative fluid. The alcohol solutions offered to the animals were increased systematically in concentrations from 3 to 30%, according to a three-bottle, two-choice technique. Tetrahydropapaveroline (THP), a tetrahydroisoquinoline derivative, was infused repeatedly into the lateral cerebral ventricle of each rat through a guide tube implanted chronically. The metabolite was dissolved in a CSF vehicle, and infused in a volume of 1.0 μl every 15 min or 4.0 μl every 30 min around the clock, for the entire 12-day period of alcohol-water self-selection. Within 3 to 6 days of the start of infusion, extraordinary amounts of alcohol were consumed which ranged as high as 8 to 17 g per kg per day. Both the racemic mixture of THP and the S-(-)-THP isomer exerted this alcohol-inducing effect, when they were infused chronically in a range of doses from 100 picograms/μl to 1.0 mu;g/μl. Control intraventricular infusions of CSF according to the same regimen had no effect on alcohol preference. The excessive intake of alcohol during the intraventricular infusions of THP persisted long after the cessation of the infusion regimen, i.e., during retests carried out at one, six and nine months' intervals. Further, when THP-treated rats were offered a simultaneous choice of a palatable solution of saccharin together with alcohol, they continued to drink large volumes of alcohol. The 24 hr patterns of fluid intake, as registered continuously by a drinkometer, revealed that alcohol drinking was typically massed within two to four bouts during the night-time interval. During this period, the blood alcohol level reached concentrations as high as 0.2%. Withdrawal-like symptoms including wet-dog shakes, elevated tail, whisker twitching and occasional convulsive episodes, were also observed in the THP-infused rats. These findings provide support for the hypothesis that an alkaloid metabolite, which may be formed in both the brain and periphery, is involved in the mechanism underlying the pathological and sustained drinking which is characteristic of the disease state of alcoholism." @default.
• W1971679339 created "2016-06-24" @default.
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• W1971679339 date "1977-07-01" @default.
• W1971679339 modified "2023-09-23" @default.
• W1971679339 title "Preference for alcohol evoked by tetrahydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat" @default.
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• W1971679339 doi "https://doi.org/10.1016/0091-3057(77)90006-5" @default.
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