Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971683221> ?p ?o ?g. }
- W1971683221 endingPage "1807" @default.
- W1971683221 startingPage "1787" @default.
- W1971683221 abstract "Abstract A structure‐guided redesign of D ‐fructose‐6‐phosphate aldolase from Escherichia coli (FSA) was devised for improving the acceptor tolerance towards α‐substituted and conformationally constrained aldehydes. FSA A129S/ R134X /A165G/S166G and L107Y/A129G/ R134X /A165G/S166G variants, where X was R , V , P , or S , were the most suited biocatalysts for dihydroxyacetone, hydroxyacetone and glycolaldehyde additions to 20 α‐substituted N ‐Cbz‐aminoaldehydes (Cbz=benzyloxycarbonyl) including pyrrolidine and piperidine derivatives. Full kinetic stereocontrol for si ‐ si face addition of the aldolase‐bound nucleophile to the N ‐Cbz‐aminoaldehyde carbonyl was observed, furnishing the corresponding D ‐ threo configured aldol adduct in >95:5 dr as assessed by NMR. After reductive amination, 47 different iminocyclitols were identified and characterized. In some examples partial racemization of the corresponding aldehyde was observed, which appears to be produced mostly during the aldol addition reactions. magnified image" @default.
- W1971683221 created "2016-06-24" @default.
- W1971683221 creator A5006847219 @default.
- W1971683221 creator A5023068003 @default.
- W1971683221 creator A5027846981 @default.
- W1971683221 creator A5041685275 @default.
- W1971683221 creator A5049493569 @default.
- W1971683221 creator A5071052081 @default.
- W1971683221 creator A5073841662 @default.
- W1971683221 date "2015-04-29" @default.
- W1971683221 modified "2023-10-16" @default.
- W1971683221 title "Structure‐Guided Engineering of <scp>D</scp>‐Fructose‐6‐Phosphate Aldolase for Improved Acceptor Tolerance in Biocatalytic Aldol Additions" @default.
- W1971683221 cites W1963980013 @default.
- W1971683221 cites W1967563200 @default.
- W1971683221 cites W1971296116 @default.
- W1971683221 cites W1984145455 @default.
- W1971683221 cites W1984431726 @default.
- W1971683221 cites W1988749945 @default.
- W1971683221 cites W2009043024 @default.
- W1971683221 cites W2026819204 @default.
- W1971683221 cites W2029877264 @default.
- W1971683221 cites W2036944788 @default.
- W1971683221 cites W2062243455 @default.
- W1971683221 cites W2063119128 @default.
- W1971683221 cites W2068917531 @default.
- W1971683221 cites W2086554780 @default.
- W1971683221 cites W2094160494 @default.
- W1971683221 cites W2103437579 @default.
- W1971683221 cites W2105229830 @default.
- W1971683221 cites W2118328098 @default.
- W1971683221 cites W2130405491 @default.
- W1971683221 cites W2150208901 @default.
- W1971683221 cites W2159134927 @default.
- W1971683221 cites W2161491354 @default.
- W1971683221 cites W2165243843 @default.
- W1971683221 cites W2169461081 @default.
- W1971683221 cites W4237324243 @default.
- W1971683221 cites W4293247451 @default.
- W1971683221 doi "https://doi.org/10.1002/adsc.201500073" @default.
- W1971683221 hasPublicationYear "2015" @default.
- W1971683221 type Work @default.
- W1971683221 sameAs 1971683221 @default.
- W1971683221 citedByCount "20" @default.
- W1971683221 countsByYear W19716832212016 @default.
- W1971683221 countsByYear W19716832212017 @default.
- W1971683221 countsByYear W19716832212018 @default.
- W1971683221 countsByYear W19716832212019 @default.
- W1971683221 countsByYear W19716832212020 @default.
- W1971683221 countsByYear W19716832212021 @default.
- W1971683221 countsByYear W19716832212022 @default.
- W1971683221 countsByYear W19716832212023 @default.
- W1971683221 crossrefType "journal-article" @default.
- W1971683221 hasAuthorship W1971683221A5006847219 @default.
- W1971683221 hasAuthorship W1971683221A5023068003 @default.
- W1971683221 hasAuthorship W1971683221A5027846981 @default.
- W1971683221 hasAuthorship W1971683221A5041685275 @default.
- W1971683221 hasAuthorship W1971683221A5049493569 @default.
- W1971683221 hasAuthorship W1971683221A5071052081 @default.
- W1971683221 hasAuthorship W1971683221A5073841662 @default.
- W1971683221 hasConcept C108204754 @default.
- W1971683221 hasConcept C146686406 @default.
- W1971683221 hasConcept C161790260 @default.
- W1971683221 hasConcept C178790620 @default.
- W1971683221 hasConcept C181199279 @default.
- W1971683221 hasConcept C185592680 @default.
- W1971683221 hasConcept C2776651935 @default.
- W1971683221 hasConcept C2776970464 @default.
- W1971683221 hasConcept C2779825165 @default.
- W1971683221 hasConcept C2779938440 @default.
- W1971683221 hasConcept C2780866112 @default.
- W1971683221 hasConcept C2781462491 @default.
- W1971683221 hasConcept C28165981 @default.
- W1971683221 hasConcept C28173026 @default.
- W1971683221 hasConcept C3488265 @default.
- W1971683221 hasConcept C60002323 @default.
- W1971683221 hasConcept C61156836 @default.
- W1971683221 hasConcept C71240020 @default.
- W1971683221 hasConceptScore W1971683221C108204754 @default.
- W1971683221 hasConceptScore W1971683221C146686406 @default.
- W1971683221 hasConceptScore W1971683221C161790260 @default.
- W1971683221 hasConceptScore W1971683221C178790620 @default.
- W1971683221 hasConceptScore W1971683221C181199279 @default.
- W1971683221 hasConceptScore W1971683221C185592680 @default.
- W1971683221 hasConceptScore W1971683221C2776651935 @default.
- W1971683221 hasConceptScore W1971683221C2776970464 @default.
- W1971683221 hasConceptScore W1971683221C2779825165 @default.
- W1971683221 hasConceptScore W1971683221C2779938440 @default.
- W1971683221 hasConceptScore W1971683221C2780866112 @default.
- W1971683221 hasConceptScore W1971683221C2781462491 @default.
- W1971683221 hasConceptScore W1971683221C28165981 @default.
- W1971683221 hasConceptScore W1971683221C28173026 @default.
- W1971683221 hasConceptScore W1971683221C3488265 @default.
- W1971683221 hasConceptScore W1971683221C60002323 @default.
- W1971683221 hasConceptScore W1971683221C61156836 @default.
- W1971683221 hasConceptScore W1971683221C71240020 @default.
- W1971683221 hasIssue "8" @default.
- W1971683221 hasLocation W19716832211 @default.
- W1971683221 hasOpenAccess W1971683221 @default.