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• W1971698434 abstract "Ring-substituted dibenzoylhydrazines are well known as nonsteroidal ecdysone agonists that cause precocious larval molt leading to death. Among them, tebufenozide (RH-5992) is used in practice as insecticide to control lepidopteran pests selectively. Recently, a new dibenzoylhydrazine, methoxyfenozide (RH-2485), with a higher activity for Lepidoptera, has been discovered. To obtain insight into the molecular mechanisms involved in the insecticidal selectivity of the dibenzoylhydrazine family, we measured the in vivo toxicity of these dibenzoylhydrazines against larval stages of the beet armyworm, Spodoptera exigua, and their action on in vitro cultured imaginal discs. We found that both nonsteroidal ecdysone agonists induced premature and lethal molting, and caused the same effect as 20-hydroxyecdysone in vitro. Furthermore, we measured the larvicidal activity against S. exigua of a series of dibenzoylhydrazines, in which ring-substituents were varied in a range of halogen, lower alkyl, OCH3, SCH3, Ph, CN, NO2, and CF3. The substituent effects on the larvicidal activity against S. exigua were very similar to that for another lepidopteran insect species Chilo suppressalis, suggesting that the molecular mechanism of action of these compounds is similar within both lepidopteran species. Arch. Insect Biochem. Physiol. 41:42–53, 1999. © 1999 Wiley-Liss, Inc." @default.
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• W1971698434 date "1999-01-01" @default.
• W1971698434 modified "2023-09-25" @default.
• W1971698434 title "Comparative ecdysteroid action of ring-substituted dibenzoylhydrazines inSpodoptera exigua" @default.
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• W1971698434 doi "https://doi.org/10.1002/(sici)1520-6327(1999)41:1<42::aid-arch7>3.0.co;2-h" @default.
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