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- W1971703943 abstract "A NF-kappaB-Twist-Snail network controls axis and mesoderm formation in Drosophila. Using translation-blocking morpholinos and hormone-regulated proteins, we demonstrate the presence of an analogous network in the early Xenopus embryo. Loss of twist (twist1) function leads to a reduction of mesoderm and neural crest markers, an increase in apoptosis, and a decrease in snail1 (snail) and snail2 (slug) mRNA levels. Injection of snail2 mRNA rescues twist's loss of function phenotypes and visa versa. In the early embryo NF-kappaB/RelA regulates twist, snail2, and snail1 mRNA levels; similarly Nodal/Smad2 regulate twist, snail2, snail1, and relA RNA levels. Both Twist and Snail2 negatively regulate levels of cerberus RNA, which encodes a Nodal, bone morphogenic protein (BMP), and Wnt inhibitor. Cerberus's anti-Nodal activity inhibits NF-kappaB activity and decreases relA RNA levels. These results reveal both conserved and unexpected regulatory interactions at the core of a vertebrate's mesodermal specification network." @default.
- W1971703943 created "2016-06-24" @default.
- W1971703943 creator A5055780182 @default.
- W1971703943 creator A5088141052 @default.
- W1971703943 date "2009-07-01" @default.
- W1971703943 modified "2023-09-25" @default.
- W1971703943 title "Unexpected functional redundancy between Twist and Slug (Snail2) and their feedback regulation of NF-κB via Nodal and Cerberus" @default.
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- W1971703943 doi "https://doi.org/10.1016/j.ydbio.2009.04.016" @default.
- W1971703943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747320" @default.
- W1971703943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19389392" @default.
- W1971703943 hasPublicationYear "2009" @default.
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