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- W1971708319 abstract "We measured changes in membrane potential (MP), extra- and intracellular potassium and intracellular sodium ion activities (aoK, aiK, and aiNa) in papillary muscle of the guinea-pig heart induced by repetitive stimulation at various frequencies and periods in vitro, using double-barrelled ion-selective microelectrodes. Stimulation (2-4Hz) depolarized the cells, and termination of stimulation induced hyperpolarization. The aiK and aiNa (stimulated at 0.20Hz) were 92.3±4.6 and 7.8±2.0mM (mean±S.D.), respectively. Prolongation of the stimulation period (0.5-2min) increased aiNa time-dependently, but there was no further increase by stimulation for longer than 3min. The increase in aiNa was dependent on stimulus frequency. After termination of the stimulation, aiNa declined exponentially. aiK slightly decreased by the stimulation (3-4Hz). aoK increased during the stimulation period, and decreased below the initial level after termination of the stimulation. Results suggest that in guinea-pig papillary muscle, the. contribution of an electrogenic component of Na-K pump to the hyperpolarization after stimulation would be small, since the hyperpolarization could be explained mostly by depletion of aoK induced by Na-K pump activity." @default.
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- W1971708319 date "1987-01-01" @default.
- W1971708319 modified "2023-09-27" @default.
- W1971708319 title "Changes in intra- and extracellular potassium and intracellular sodium activities induced by repetitive stimulation and their relation to membrane potential in guinea-pig papillary muscle." @default.
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- W1971708319 doi "https://doi.org/10.2170/jjphysiol.37.797" @default.
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