Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971715231> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1971715231 endingPage "61" @default.
- W1971715231 startingPage "51" @default.
- W1971715231 abstract "We investigated the opsonic activity of the serum factors affecting phagocytosis of Cryptococcus neoformans in vitro to elucidate the role of humoral factors in the host defense mechanisms against cryptococcosis. Two strains of C. neoformans, one heavily and one weakly encapsulated, were used. Guinea pig peripheral blood leukocytes (PBLs) were used for phagocytosis. The viable weakly encapsulated cells were ingested effectively by PBLs, in the presence of guinea pig normal fresh serum, while the heavily encapsulated cells were not ingested. Neither immune serum, its IgG fraction alone, nor heated serum promoted the phagocytosis of either the weakly or heavily encapsulated strain. On the other hand, immune serum promoted adherence of PBLs to viable cells of the heavily encapsulated strain, forming rosettes in the presence of fresh serum. A substantial amount of C3b component was detected on yeast cells when weakly encapsulated cells were incubated with human fresh serum, or heavily encapsulated cells were incubated with rabbit immune serum together with human fresh serum. Serum chelation experiments also indicated that the factors involved in the alternative complement pathway are opsonins for the weakly encapsulated strain. These results suggest that the alternative pathway plays an important normal opsonic role for weakly encapsulated strains and that specific antibody plays an immune opsonic role for heavily encapsulated strains of C. neoformans via the classical pathway of complement activation." @default.
- W1971715231 created "2016-06-24" @default.
- W1971715231 creator A5052076883 @default.
- W1971715231 creator A5065537761 @default.
- W1971715231 creator A5081083706 @default.
- W1971715231 creator A5084351823 @default.
- W1971715231 date "1984-01-01" @default.
- W1971715231 modified "2023-09-23" @default.
- W1971715231 title "Role of Serum Factors in the Phagocytosis of Weakly or Heavily EncapsulatedCryptococcus neoformansStrains by Guinea Pig Peripheral Blood Leukocytes" @default.
- W1971715231 cites W1595161187 @default.
- W1971715231 cites W1606519489 @default.
- W1971715231 cites W1904766181 @default.
- W1971715231 cites W1933529542 @default.
- W1971715231 cites W1963286479 @default.
- W1971715231 cites W1968003893 @default.
- W1971715231 cites W1980807435 @default.
- W1971715231 cites W1991830969 @default.
- W1971715231 cites W2017359321 @default.
- W1971715231 cites W2074597709 @default.
- W1971715231 cites W2114482761 @default.
- W1971715231 cites W2144812225 @default.
- W1971715231 cites W2155127516 @default.
- W1971715231 cites W2171272249 @default.
- W1971715231 cites W2319070017 @default.
- W1971715231 cites W2328287318 @default.
- W1971715231 cites W2406112407 @default.
- W1971715231 cites W4321835893 @default.
- W1971715231 doi "https://doi.org/10.1111/j.1348-0421.1984.tb02946.x" @default.
- W1971715231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6374392" @default.
- W1971715231 hasPublicationYear "1984" @default.
- W1971715231 type Work @default.
- W1971715231 sameAs 1971715231 @default.
- W1971715231 citedByCount "12" @default.
- W1971715231 countsByYear W19717152312014 @default.
- W1971715231 crossrefType "journal-article" @default.
- W1971715231 hasAuthorship W1971715231A5052076883 @default.
- W1971715231 hasAuthorship W1971715231A5065537761 @default.
- W1971715231 hasAuthorship W1971715231A5081083706 @default.
- W1971715231 hasAuthorship W1971715231A5084351823 @default.
- W1971715231 hasConcept C111684460 @default.
- W1971715231 hasConcept C134018914 @default.
- W1971715231 hasConcept C159654299 @default.
- W1971715231 hasConcept C160448771 @default.
- W1971715231 hasConcept C168507396 @default.
- W1971715231 hasConcept C171279029 @default.
- W1971715231 hasConcept C189446657 @default.
- W1971715231 hasConcept C202751555 @default.
- W1971715231 hasConcept C203014093 @default.
- W1971715231 hasConcept C2777893358 @default.
- W1971715231 hasConcept C2778815084 @default.
- W1971715231 hasConcept C2779413141 @default.
- W1971715231 hasConcept C55493867 @default.
- W1971715231 hasConcept C86803240 @default.
- W1971715231 hasConcept C8891405 @default.
- W1971715231 hasConcept C89372155 @default.
- W1971715231 hasConcept C89423630 @default.
- W1971715231 hasConceptScore W1971715231C111684460 @default.
- W1971715231 hasConceptScore W1971715231C134018914 @default.
- W1971715231 hasConceptScore W1971715231C159654299 @default.
- W1971715231 hasConceptScore W1971715231C160448771 @default.
- W1971715231 hasConceptScore W1971715231C168507396 @default.
- W1971715231 hasConceptScore W1971715231C171279029 @default.
- W1971715231 hasConceptScore W1971715231C189446657 @default.
- W1971715231 hasConceptScore W1971715231C202751555 @default.
- W1971715231 hasConceptScore W1971715231C203014093 @default.
- W1971715231 hasConceptScore W1971715231C2777893358 @default.
- W1971715231 hasConceptScore W1971715231C2778815084 @default.
- W1971715231 hasConceptScore W1971715231C2779413141 @default.
- W1971715231 hasConceptScore W1971715231C55493867 @default.
- W1971715231 hasConceptScore W1971715231C86803240 @default.
- W1971715231 hasConceptScore W1971715231C8891405 @default.
- W1971715231 hasConceptScore W1971715231C89372155 @default.
- W1971715231 hasConceptScore W1971715231C89423630 @default.
- W1971715231 hasIssue "1" @default.
- W1971715231 hasLocation W19717152311 @default.
- W1971715231 hasLocation W19717152312 @default.
- W1971715231 hasOpenAccess W1971715231 @default.
- W1971715231 hasPrimaryLocation W19717152311 @default.
- W1971715231 hasRelatedWork W1773077102 @default.
- W1971715231 hasRelatedWork W1935132701 @default.
- W1971715231 hasRelatedWork W1966293644 @default.
- W1971715231 hasRelatedWork W1971715231 @default.
- W1971715231 hasRelatedWork W1976914087 @default.
- W1971715231 hasRelatedWork W2096501606 @default.
- W1971715231 hasRelatedWork W2119935989 @default.
- W1971715231 hasRelatedWork W2333559000 @default.
- W1971715231 hasRelatedWork W2419190643 @default.
- W1971715231 hasRelatedWork W987593488 @default.
- W1971715231 hasVolume "28" @default.
- W1971715231 isParatext "false" @default.
- W1971715231 isRetracted "false" @default.
- W1971715231 magId "1971715231" @default.
- W1971715231 workType "article" @default.