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• W1971716189 endingPage "174" @default.
• W1971716189 startingPage "171" @default.
• W1971716189 abstract "This study was performed to obtain information on the enzymatic background to the antiviral activity of acyclic guanosine analogs. Five acyclic guanosine analogs, the (R)- and (S)-enantiomers of 9-(3,4-dihydroxybutyl)guanine, 9-(4-hydroxybutyl)guanine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine, were compared in enzyme kinetic experiments using purified varicella-zoster virus and human placenta mitochondrial thymidine kinase (TK). All analogs showed competitive patterns of inhibition in the phosphorylation of thymidine by varicella-zoster virus TK, but only low affinities and phosphorylation rates were observed. No affinity for the mitochondrial TK was observed for any of the analogs." @default.
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• W1971716189 date "1986-01-01" @default.
• W1971716189 modified "2023-10-18" @default.
• W1971716189 title "Acyclic guanosine analogs as substrates for varicella-zoster virus thymidine kinase" @default.
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• W1971716189 doi "https://doi.org/10.1128/aac.29.1.171" @default.
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