Matches in SemOpenAlex for { <https://semopenalex.org/work/W197172205> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W197172205 endingPage "56.1" @default.
- W197172205 startingPage "56.1" @default.
- W197172205 abstract "Abstract Oropharyngeal candidiasis (OPC, thrush) is an opportunistic infection caused by the commensal fungus Candida albicans. OPC is an AIDS-defining illness, and is also common in patients on chemotherapy and those with congenital immunodeficiencies. An understanding of immunity to Candida has recently begun to unfold with the identification of fungal pattern recognition receptors such as dectins, which trigger protective Th17 responses in the mucosa. Hyper-IgE syndrome (HIES/Job’s Syndrome) is a rare congenital immunodeficiency characterized by dominant-negative mutations in STAT-3. STAT-3 is downstream of the Th17-inductive cytokines IL-6 and IL-23, and hence HIES patients exhibit dramatic Th17 defects. Striingly, HIES patients develop oral and mucocutaneous candidiasis, supporting a protective role for Th17 cells. However, the Th17-dependent mechanisms of immunity in OPC are poorly defined. An often-unappreciated aspect of oral immunity is saliva, which is rich in anti-microbial proteins (AMPs) and exerts direct antifungal activity. We found that both Th17-deficient mice and HIES patients show significant impairment in salivary candidacidal activity. In HIES, this was linked to reduction in AMPs, such as β-defensin 2 and Histatins. Moreover, IL-17 induces histatins in cultured salivary gland cells. This is the first demonstration that the Th17 axis of immunity is associated with salivary activity, and provides a mechanism for the severe susceptibility of HIES patients to OPC." @default.
- W197172205 created "2016-06-24" @default.
- W197172205 creator A5008644590 @default.
- W197172205 creator A5025146971 @default.
- W197172205 creator A5036961404 @default.
- W197172205 creator A5049895849 @default.
- W197172205 creator A5063867007 @default.
- W197172205 creator A5079363879 @default.
- W197172205 creator A5080366618 @default.
- W197172205 creator A5081675173 @default.
- W197172205 date "2011-04-01" @default.
- W197172205 modified "2023-09-23" @default.
- W197172205 title "New mechanism of mucosal immunity in oral candidiasis: insights from Hyper-IgE (STAT3-deficient) patients (56.1)" @default.
- W197172205 doi "https://doi.org/10.4049/jimmunol.186.supp.56.1" @default.
- W197172205 hasPublicationYear "2011" @default.
- W197172205 type Work @default.
- W197172205 sameAs 197172205 @default.
- W197172205 citedByCount "0" @default.
- W197172205 crossrefType "journal-article" @default.
- W197172205 hasAuthorship W197172205A5008644590 @default.
- W197172205 hasAuthorship W197172205A5025146971 @default.
- W197172205 hasAuthorship W197172205A5036961404 @default.
- W197172205 hasAuthorship W197172205A5049895849 @default.
- W197172205 hasAuthorship W197172205A5063867007 @default.
- W197172205 hasAuthorship W197172205A5079363879 @default.
- W197172205 hasAuthorship W197172205A5080366618 @default.
- W197172205 hasAuthorship W197172205A5081675173 @default.
- W197172205 hasConcept C126322002 @default.
- W197172205 hasConcept C141105273 @default.
- W197172205 hasConcept C159654299 @default.
- W197172205 hasConcept C203014093 @default.
- W197172205 hasConcept C2776422140 @default.
- W197172205 hasConcept C2779134260 @default.
- W197172205 hasConcept C2779341262 @default.
- W197172205 hasConcept C2780917455 @default.
- W197172205 hasConcept C504460877 @default.
- W197172205 hasConcept C71924100 @default.
- W197172205 hasConcept C86803240 @default.
- W197172205 hasConcept C8891405 @default.
- W197172205 hasConcept C89423630 @default.
- W197172205 hasConceptScore W197172205C126322002 @default.
- W197172205 hasConceptScore W197172205C141105273 @default.
- W197172205 hasConceptScore W197172205C159654299 @default.
- W197172205 hasConceptScore W197172205C203014093 @default.
- W197172205 hasConceptScore W197172205C2776422140 @default.
- W197172205 hasConceptScore W197172205C2779134260 @default.
- W197172205 hasConceptScore W197172205C2779341262 @default.
- W197172205 hasConceptScore W197172205C2780917455 @default.
- W197172205 hasConceptScore W197172205C504460877 @default.
- W197172205 hasConceptScore W197172205C71924100 @default.
- W197172205 hasConceptScore W197172205C86803240 @default.
- W197172205 hasConceptScore W197172205C8891405 @default.
- W197172205 hasConceptScore W197172205C89423630 @default.
- W197172205 hasIssue "1_Supplement" @default.
- W197172205 hasLocation W1971722051 @default.
- W197172205 hasOpenAccess W197172205 @default.
- W197172205 hasPrimaryLocation W1971722051 @default.
- W197172205 hasRelatedWork W1929090722 @default.
- W197172205 hasRelatedWork W1983740111 @default.
- W197172205 hasRelatedWork W1988863520 @default.
- W197172205 hasRelatedWork W1995617640 @default.
- W197172205 hasRelatedWork W2021312696 @default.
- W197172205 hasRelatedWork W203390905 @default.
- W197172205 hasRelatedWork W2056919855 @default.
- W197172205 hasRelatedWork W2070955171 @default.
- W197172205 hasRelatedWork W2087982072 @default.
- W197172205 hasRelatedWork W2545935326 @default.
- W197172205 hasVolume "186" @default.
- W197172205 isParatext "false" @default.
- W197172205 isRetracted "false" @default.
- W197172205 magId "197172205" @default.
- W197172205 workType "article" @default.