FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971725972> ?p ?o ?g. }

• W1971725972 endingPage "1887" @default.
• W1971725972 startingPage "1885" @default.
• W1971725972 abstract "In our previous study, we described 26 clinical pneumococci with heterogeneous resistance to telithromycin (TEL). In this resistance type, separate colonies grew inside the inhibition zone around the TEL disk in a disk diffusion test (8). In this study we investigated the molecular epidemiology of these 26 isolates and compared them to erm(B)-positive but TEL-susceptible (Tels) pneumococci (n = 66) (9). Published methods were used for antimicrobial susceptibility testing (7), serotyping (3), pulsed-field gel electrophoresis (PFGE) typing (5, 4), and multilocus sequence typing (MLST) (1). PFGE was performed for all TEL-resistant (Telr) isolates, for 3 zone isolates (8), and for 22 randomly selected Tels, erm(B)-positive isolates, but MLST typing and serotyping were performed only for Telr isolates. Our results were compared to international databases (www.mlst.net and www.sph.emory.edu/PMEN).The clinical characteristics, antimicrobial susceptibilities, PFGE profiles, and sequence types (STs) of the isolates are summarized in Table ​Table1.1. Penicillin nonsusceptibility (MIC of ≥0.125 μg/ml) was less frequent among erm(B)-positive Telr isolates (4/26) than among erm(B)-positive Tels isolates (50/66) (P < 0.0001, Fisher's exact test). The same applied to penicillin and tetracycline coresistance. None of the isolates was resistant to levofloxacin or linezolid. The most frequent serotype was 19A. Telr isolates were distributed among 7 distinct PFGE types, of which type A was the most frequent with 19 isolates. Tels erm(B) isolates had more heterogeneous PFGE patterns, since 12 different PFGE types were detected among 22 Tels isolates (Fig. ​(Fig.11).FIG. 1.Dendrogram and PFGE patterns of 26 Telr, erm(B)-positive pneumococci. Telr isolates are in boldface. Respective patterns of 22 erm(B)-positive but Tels isolates are also presented. Three isolates designated with the letter V are zone isolates (isolates ...TABLE 1.Summary of clinical and molecular data for 26 clinical pneumococcal isolates with heterogeneous resistance to telithromycinMLST types 193, 271, and 273, found among our isolates, are representatives of global pneumococcal clones. ST 193 belongs to the pneumococcal global clone Greece21-30, which has been found in Greece, Brazil, the United Kingdom, and Vietnam (12, 13). The clone was reported to be penicillin susceptible but otherwise multidrug resistant, which also applies to our isolates. ST 273 is a representative of the penicillin-susceptible but erythromycin-resistant PMEN clone, Greece6B-22. Apart from Greece, this clone has been detected in Iceland, Israel, Portugal, Italy, Germany, and Switzerland (6, 11). ST 133 has been detected in Spain (www.mlst.net). ST 271 is a single-locus variant of a multidrug-resistant Taiwanese 19F clone, ST 236 (10). In one international study, ST 271 was detected worldwide and more than 85% of pneumococcal isolates with a double resistance mechanism, erm(B) and mef(E), belonged to this clonal complex (2). Our ST 271 isolate also had a double resistance mechanism. The other isolate in this study with a double mechanism had a novel ST, ST 2248. Two additional new MLST types were detected: ST 2306 and ST 2307.The presence of more than one PFGE and MLST type among Telr isolates suggests that the capability for expressing TEL resistance has arisen several times in S. pneumoniae. It is also likely that TEL resistance is an older phenomenon and would not have been caused by TEL selection pressure, because all of our strains were collected in 2002, just before TEL was introduced into clinical practice in Finland. The fact that all of our isolates were of clinical origin means that this type of resistance can survive in the bacterial population and cause diseases to humans. It is also noticeable that six of these isolates were from invasive infections. Our results indicate that pneumococci with heterogeneous TEL resistance can be found in other countries, because many of our strains belonged to global clones. However, this resistance type is difficult to detect using the dilution method (8). We recommend that routine testing of TEL susceptibility of pneumococci be done with the disc diffusion method in a 5%-CO2 atmosphere, especially in areas where erm(B) is a common resistance mechanism." @default.
• W1971725972 created "2016-06-24" @default.
• W1971725972 creator A5010352311 @default.
• W1971725972 creator A5010892597 @default.
• W1971725972 creator A5016263118 @default.
• W1971725972 creator A5028115955 @default.
• W1971725972 creator A5032013316 @default.
• W1971725972 creator A5039375684 @default.
• W1971725972 creator A5077503732 @default.
• W1971725972 creator A5081255276 @default.
• W1971725972 creator A5083847876 @default.
• W1971725972 creator A5064019484 @default.
• W1971725972 date "2007-05-01" @default.
• W1971725972 modified "2023-10-14" @default.
• W1971725972 title "Molecular Epidemiology of Telithromycin-Resistant Pneumococci in Finland" @default.
• W1971725972 cites W1505888191 @default.
• W1971725972 cites W2035892027 @default.
• W1971725972 cites W2086660656 @default.
• W1971725972 cites W2093733084 @default.
• W1971725972 cites W2100499274 @default.
• W1971725972 cites W2104715865 @default.
• W1971725972 cites W2110488032 @default.
• W1971725972 cites W2122845481 @default.
• W1971725972 cites W2131654847 @default.
• W1971725972 cites W2134232244 @default.
• W1971725972 cites W2134606926 @default.
• W1971725972 cites W2142839218 @default.
• W1971725972 cites W2161157728 @default.
• W1971725972 doi "https://doi.org/10.1128/aac.00187-07" @default.
• W1971725972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855529" @default.
• W1971725972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17325224" @default.
• W1971725972 hasPublicationYear "2007" @default.
• W1971725972 type Work @default.
• W1971725972 sameAs 1971725972 @default.
• W1971725972 citedByCount "0" @default.
• W1971725972 crossrefType "journal-article" @default.
• W1971725972 hasAuthorship W1971725972A5010352311 @default.
• W1971725972 hasAuthorship W1971725972A5010892597 @default.
• W1971725972 hasAuthorship W1971725972A5016263118 @default.
• W1971725972 hasAuthorship W1971725972A5028115955 @default.
• W1971725972 hasAuthorship W1971725972A5032013316 @default.
• W1971725972 hasAuthorship W1971725972A5039375684 @default.
• W1971725972 hasAuthorship W1971725972A5064019484 @default.
• W1971725972 hasAuthorship W1971725972A5077503732 @default.
• W1971725972 hasAuthorship W1971725972A5081255276 @default.
• W1971725972 hasAuthorship W1971725972A5083847876 @default.
• W1971725972 hasBestOaLocation W19717259722 @default.
• W1971725972 hasConcept C104317684 @default.
• W1971725972 hasConcept C107130276 @default.
• W1971725972 hasConcept C126322002 @default.
• W1971725972 hasConcept C135763542 @default.
• W1971725972 hasConcept C159047783 @default.
• W1971725972 hasConcept C2780810561 @default.
• W1971725972 hasConcept C2780894585 @default.
• W1971725972 hasConcept C2781253189 @default.
• W1971725972 hasConcept C3019249092 @default.
• W1971725972 hasConcept C501593827 @default.
• W1971725972 hasConcept C54355233 @default.
• W1971725972 hasConcept C71924100 @default.
• W1971725972 hasConcept C86803240 @default.
• W1971725972 hasConcept C89423630 @default.
• W1971725972 hasConcept C97669555 @default.
• W1971725972 hasConceptScore W1971725972C104317684 @default.
• W1971725972 hasConceptScore W1971725972C107130276 @default.
• W1971725972 hasConceptScore W1971725972C126322002 @default.
• W1971725972 hasConceptScore W1971725972C135763542 @default.
• W1971725972 hasConceptScore W1971725972C159047783 @default.
• W1971725972 hasConceptScore W1971725972C2780810561 @default.
• W1971725972 hasConceptScore W1971725972C2780894585 @default.
• W1971725972 hasConceptScore W1971725972C2781253189 @default.
• W1971725972 hasConceptScore W1971725972C3019249092 @default.
• W1971725972 hasConceptScore W1971725972C501593827 @default.
• W1971725972 hasConceptScore W1971725972C54355233 @default.
• W1971725972 hasConceptScore W1971725972C71924100 @default.
• W1971725972 hasConceptScore W1971725972C86803240 @default.
• W1971725972 hasConceptScore W1971725972C89423630 @default.
• W1971725972 hasConceptScore W1971725972C97669555 @default.
• W1971725972 hasIssue "5" @default.
• W1971725972 hasLocation W19717259721 @default.
• W1971725972 hasLocation W19717259722 @default.
• W1971725972 hasLocation W19717259723 @default.
• W1971725972 hasLocation W19717259724 @default.
• W1971725972 hasOpenAccess W1971725972 @default.
• W1971725972 hasPrimaryLocation W19717259721 @default.
• W1971725972 hasRelatedWork W1804686097 @default.
• W1971725972 hasRelatedWork W1972321258 @default.
• W1971725972 hasRelatedWork W1979157949 @default.
• W1971725972 hasRelatedWork W2014546133 @default.
• W1971725972 hasRelatedWork W2017173899 @default.
• W1971725972 hasRelatedWork W2030034943 @default.
• W1971725972 hasRelatedWork W2036349430 @default.
• W1971725972 hasRelatedWork W2058341983 @default.
• W1971725972 hasRelatedWork W2117377748 @default.
• W1971725972 hasRelatedWork W2133528167 @default.
• W1971725972 hasVolume "51" @default.
• W1971725972 isParatext "false" @default.
• W1971725972 isRetracted "false" @default.
• W1971725972 magId "1971725972" @default.

• next