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- W1971732087 abstract "Presented here is a cell-suspension model for positive selection using thymocytes from αβ -TCR (H-2D b -restricted) transgenic mice specific to the lymphocytic choriomeningitis virus (LCMV) on a nonselecting MHC background (H-2 d or TAP-1 –/–), cocultured with freshly isolated adult thymus stromal cells of the selecting MHC type. The thymic stromal cells alone induced positive selection of functional CD4 - CD8 + cells whose kinetics and efficiency were enhanced by nominal peptide. Fibroblasts expressing the selecting MHC alone did not induce positive selection; however, together with nonselecting stroma and nominal peptide, there was inefficient positive. These results suggest multiple signaling in positive selection with selection events able to occur on multiple-cell types. The ease with which this model can be manipulated should greatly facilitate the resolution of the mechanisms of positive selection in normal and pathological states." @default.
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- W1971732087 date "1998-01-01" @default.
- W1971732087 modified "2023-10-18" @default.
- W1971732087 title "An Adult Thymic Stromal-Cell Suspension Model for<i>in Vitro</i>Positive Selection" @default.
- W1971732087 doi "https://doi.org/10.1155/1998/10534" @default.
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