Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971736215> ?p ?o ?g. }
- W1971736215 endingPage "280" @default.
- W1971736215 startingPage "275" @default.
- W1971736215 abstract "Several studies indicate that stress can produce remarkable effects on neurotrophic factors. In this regard, hippocampus is the most interesting structure of the brain because of its broad involvement in behavioral and neuroendocrine phenomena. In the present study, we investigated the effect of stress on hippocampal prosaposin, which is known to act as a neurotrophic and neuroprotective factor. Rats subjected to restraint stress (120 min) had a significant and transient reduction of hippocampal, but not hypothalamic, prosaposin full-length protein. Indeed, when this stressful stimulus was applied daily for 3 days, no differences were detected in comparison with naive rats. To investigate the role of glucocorticoids in the stress-induced decrease in hippocampal prosaposin, adrenalectomized and corticosterone-treated rats were studied. The results indicate that adrenalectomized rats behave as intact animals. This finding indicates that the absence of endogenous corticosterone does not prevent a decrease in hippocampal prosaposin. When an increase of corticosterone was achieved through exogenous administration, hippocampal prosaposin concentrations were unchanged in comparison with vehicle-injected (sesame oil) rats. These results led to the conclusion that stress, not via an increase of glucocorticoid hormone, transiently reduces hippocampal prosaposin levels. This phenomenon is followed by rapid recovery of the neurotrophin level, even when the stress stimulus persists." @default.
- W1971736215 created "2016-06-24" @default.
- W1971736215 creator A5014531813 @default.
- W1971736215 creator A5041390788 @default.
- W1971736215 creator A5048821169 @default.
- W1971736215 creator A5060904495 @default.
- W1971736215 creator A5073735460 @default.
- W1971736215 creator A5074726037 @default.
- W1971736215 creator A5081857144 @default.
- W1971736215 date "2004-01-01" @default.
- W1971736215 modified "2023-09-25" @default.
- W1971736215 title "Hippocampal prosaposin changes during stress: A glucocorticoid-independent event" @default.
- W1971736215 cites W1604414616 @default.
- W1971736215 cites W1647156299 @default.
- W1971736215 cites W1914011667 @default.
- W1971736215 cites W1967105375 @default.
- W1971736215 cites W1968766044 @default.
- W1971736215 cites W1972818453 @default.
- W1971736215 cites W1977143695 @default.
- W1971736215 cites W1979668038 @default.
- W1971736215 cites W1980166225 @default.
- W1971736215 cites W1984537735 @default.
- W1971736215 cites W1987432599 @default.
- W1971736215 cites W2008301967 @default.
- W1971736215 cites W2013154464 @default.
- W1971736215 cites W2015051992 @default.
- W1971736215 cites W2015126957 @default.
- W1971736215 cites W2032953590 @default.
- W1971736215 cites W2033803679 @default.
- W1971736215 cites W2037915126 @default.
- W1971736215 cites W2039728950 @default.
- W1971736215 cites W2044127038 @default.
- W1971736215 cites W2045414227 @default.
- W1971736215 cites W2050137926 @default.
- W1971736215 cites W2067388092 @default.
- W1971736215 cites W2074802748 @default.
- W1971736215 cites W2076987224 @default.
- W1971736215 cites W2081699776 @default.
- W1971736215 cites W2085992114 @default.
- W1971736215 cites W2087351475 @default.
- W1971736215 cites W2088514907 @default.
- W1971736215 cites W2092192085 @default.
- W1971736215 cites W2092906590 @default.
- W1971736215 cites W2098552880 @default.
- W1971736215 cites W2101333441 @default.
- W1971736215 cites W2109158936 @default.
- W1971736215 cites W2161400325 @default.
- W1971736215 cites W2165030901 @default.
- W1971736215 cites W4237012674 @default.
- W1971736215 doi "https://doi.org/10.1002/hipo.10192" @default.
- W1971736215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15132426" @default.
- W1971736215 hasPublicationYear "2004" @default.
- W1971736215 type Work @default.
- W1971736215 sameAs 1971736215 @default.
- W1971736215 citedByCount "5" @default.
- W1971736215 countsByYear W19717362152012 @default.
- W1971736215 countsByYear W19717362152017 @default.
- W1971736215 crossrefType "journal-article" @default.
- W1971736215 hasAuthorship W1971736215A5014531813 @default.
- W1971736215 hasAuthorship W1971736215A5041390788 @default.
- W1971736215 hasAuthorship W1971736215A5048821169 @default.
- W1971736215 hasAuthorship W1971736215A5060904495 @default.
- W1971736215 hasAuthorship W1971736215A5073735460 @default.
- W1971736215 hasAuthorship W1971736215A5074726037 @default.
- W1971736215 hasAuthorship W1971736215A5081857144 @default.
- W1971736215 hasConcept C126322002 @default.
- W1971736215 hasConcept C134018914 @default.
- W1971736215 hasConcept C148762608 @default.
- W1971736215 hasConcept C15744967 @default.
- W1971736215 hasConcept C16613235 @default.
- W1971736215 hasConcept C169760540 @default.
- W1971736215 hasConcept C185592680 @default.
- W1971736215 hasConcept C25498285 @default.
- W1971736215 hasConcept C2779918689 @default.
- W1971736215 hasConcept C2780352252 @default.
- W1971736215 hasConcept C2780841215 @default.
- W1971736215 hasConcept C2781161787 @default.
- W1971736215 hasConcept C542102704 @default.
- W1971736215 hasConcept C71315377 @default.
- W1971736215 hasConcept C71924100 @default.
- W1971736215 hasConceptScore W1971736215C126322002 @default.
- W1971736215 hasConceptScore W1971736215C134018914 @default.
- W1971736215 hasConceptScore W1971736215C148762608 @default.
- W1971736215 hasConceptScore W1971736215C15744967 @default.
- W1971736215 hasConceptScore W1971736215C16613235 @default.
- W1971736215 hasConceptScore W1971736215C169760540 @default.
- W1971736215 hasConceptScore W1971736215C185592680 @default.
- W1971736215 hasConceptScore W1971736215C25498285 @default.
- W1971736215 hasConceptScore W1971736215C2779918689 @default.
- W1971736215 hasConceptScore W1971736215C2780352252 @default.
- W1971736215 hasConceptScore W1971736215C2780841215 @default.
- W1971736215 hasConceptScore W1971736215C2781161787 @default.
- W1971736215 hasConceptScore W1971736215C542102704 @default.
- W1971736215 hasConceptScore W1971736215C71315377 @default.
- W1971736215 hasConceptScore W1971736215C71924100 @default.
- W1971736215 hasIssue "3" @default.
- W1971736215 hasLocation W19717362151 @default.
- W1971736215 hasLocation W19717362152 @default.