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- W1971736794 abstract "The effect of chronic oral treatment with clozapine (20 mg/kg daily for 21 days) on the extracellular concentrations of dopamine, dihydroxyphenylacetic acid and homovanillic acid in the dorsolateral anterior striatum, nucleus accumbens and frontal cortex was studied by microdialysis in conscious rats. Basal levels of dopamine and its metabolites in the three brain regions of rats treated chronically with clozapine were not significantly different from those of vehicle-treated rats. A subcutaneous challenge dose of clozapine (20 mg/kg) significantly increased the extracellular concentrations of dopamine and its metabolites in the three brain regions, with no differences between chronic vehicle- and clozapine-treated rats." @default.
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- W1971736794 date "1995-01-01" @default.
- W1971736794 modified "2023-09-24" @default.
- W1971736794 title "Further studies on the effects of chronic clozapine on regional extracellular dopamine levels in the brain of conscious rats" @default.
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- W1971736794 doi "https://doi.org/10.1016/0006-8993(94)01301-w" @default.
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