FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971758359> ?p ?o ?g. }

• W1971758359 endingPage "94" @default.
• W1971758359 startingPage "85" @default.
• W1971758359 abstract "The purposes of the present study were to determine if recombinant human transforming growth factor-beta-2 (rhTGF-beta2) enhances bone ingrowth into porous-coated implants and bone regeneration in gaps between the implant and surrounding host bone. The implants were placed bilaterally for four weeks in the proximal humeri of skeletally mature, adult male dogs in the presence of a 3-mm gap. In three treatment groups of animals, the test implant was treated with hydroxyapatite/tricalcium phosphate (HA/TCP) and rhTGF-beta2 in buffer at a dose per implant of 1.2 microg (n = 6), 12 microg (n = 7), or 120 microg (n = 7) and placed in the left humerus. In these same animals, an internal control implant treated only with HA/TCP and buffer was placed in the right humerus. In a non-TGF-beta treated external control group of animals (n = 7), one implant was treated with HA/TCP while the contralateral implant was not treated with the ceramic. In vitro analyses showed that approximately 15%, of the applied dose was released within 120 h with most of the release occurring in the first 24 h. The TGF-beta treated implants had significantly more bone ingrowth than the controls with the greatest effect in the 12 microg/implant group (a 2.2-fold increase over the paired internal control (P = 0.004) and a 4-fold increase over the external control (P < 0.001)). The TGF-beta treated implants had significantly more bone formation in the gap than the controls with the greatest effect in the 12 and 120 microg groups (1.8-fold increases over the paired internal controls (P = 0.003 and P = 0.012, respectively) and 2.8-fold increases over the external controls (P < 0.001 and P = 0.001, respectively)). Compared to the external controls, the internal control implants tended to have more bone ingrowth (1.9-fold increase, P = 0.066) and had significantly more bone formation in the gap (1.7-fold increase. P = 0.008). Thus, application of rhTGF-beta2 to a porous-coated implant-stimulated local bone ingrowth and gap healing in a weakly dose-dependent manner and stimulated bone regeneration in the 3-mm gap surrounding the contralateral control implant, a site remote from the local treatment with the growth factor." @default.
• W1971758359 created "2016-06-24" @default.
• W1971758359 creator A5001757741 @default.
• W1971758359 creator A5035311437 @default.
• W1971758359 creator A5052821639 @default.
• W1971758359 creator A5063494190 @default.
• W1971758359 creator A5066522140 @default.
• W1971758359 creator A5070227771 @default.
• W1971758359 creator A5078028662 @default.
• W1971758359 creator A5087147970 @default.
• W1971758359 date "2001-01-01" @default.
• W1971758359 modified "2023-09-27" @default.
• W1971758359 title "Locally delivered rhTGF-β2 enhances bone ingrowth and bone regeneration at local and remote sites of skeletal injury" @default.
• W1971758359 cites W1966311763 @default.
• W1971758359 cites W1968470656 @default.
• W1971758359 cites W1978514667 @default.
• W1971758359 cites W1983105817 @default.
• W1971758359 cites W1987408592 @default.
• W1971758359 cites W1996561250 @default.
• W1971758359 cites W1998535733 @default.
• W1971758359 cites W2000072845 @default.
• W1971758359 cites W2030018091 @default.
• W1971758359 cites W2030163851 @default.
• W1971758359 cites W2034364335 @default.
• W1971758359 cites W2035683007 @default.
• W1971758359 cites W2036236605 @default.
• W1971758359 cites W2048973232 @default.
• W1971758359 cites W2049904686 @default.
• W1971758359 cites W2050183943 @default.
• W1971758359 cites W2050816771 @default.
• W1971758359 cites W2059325835 @default.
• W1971758359 cites W2062661523 @default.
• W1971758359 cites W2064201255 @default.
• W1971758359 cites W2071078896 @default.
• W1971758359 cites W2077123614 @default.
• W1971758359 cites W2078192317 @default.
• W1971758359 cites W2085047406 @default.
• W1971758359 cites W2089797394 @default.
• W1971758359 cites W2094954133 @default.
• W1971758359 cites W2111029980 @default.
• W1971758359 cites W2111100707 @default.
• W1971758359 cites W2119491066 @default.
• W1971758359 cites W2121741505 @default.
• W1971758359 cites W2121755419 @default.
• W1971758359 cites W2145293649 @default.
• W1971758359 cites W2162839071 @default.
• W1971758359 cites W2168794355 @default.
• W1971758359 cites W2244585777 @default.
• W1971758359 cites W256984861 @default.
• W1971758359 cites W4300383945 @default.
• W1971758359 cites W4302598969 @default.
• W1971758359 cites W4360754214 @default.
• W1971758359 doi "https://doi.org/10.1016/s0736-0266(00)00015-2" @default.
• W1971758359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11332625" @default.
• W1971758359 hasPublicationYear "2001" @default.
• W1971758359 type Work @default.
• W1971758359 sameAs 1971758359 @default.
• W1971758359 citedByCount "60" @default.
• W1971758359 countsByYear W19717583592012 @default.
• W1971758359 countsByYear W19717583592013 @default.
• W1971758359 countsByYear W19717583592014 @default.
• W1971758359 countsByYear W19717583592015 @default.
• W1971758359 countsByYear W19717583592016 @default.
• W1971758359 countsByYear W19717583592017 @default.
• W1971758359 countsByYear W19717583592018 @default.
• W1971758359 countsByYear W19717583592020 @default.
• W1971758359 countsByYear W19717583592021 @default.
• W1971758359 countsByYear W19717583592022 @default.
• W1971758359 crossrefType "journal-article" @default.
• W1971758359 hasAuthorship W1971758359A5001757741 @default.
• W1971758359 hasAuthorship W1971758359A5035311437 @default.
• W1971758359 hasAuthorship W1971758359A5052821639 @default.
• W1971758359 hasAuthorship W1971758359A5063494190 @default.
• W1971758359 hasAuthorship W1971758359A5066522140 @default.
• W1971758359 hasAuthorship W1971758359A5070227771 @default.
• W1971758359 hasAuthorship W1971758359A5078028662 @default.
• W1971758359 hasAuthorship W1971758359A5087147970 @default.
• W1971758359 hasConcept C105702510 @default.
• W1971758359 hasConcept C141071460 @default.
• W1971758359 hasConcept C171056886 @default.
• W1971758359 hasConcept C199343813 @default.
• W1971758359 hasConcept C2776206872 @default.
• W1971758359 hasConcept C2781411149 @default.
• W1971758359 hasConcept C71924100 @default.
• W1971758359 hasConcept C86803240 @default.
• W1971758359 hasConcept C95444343 @default.
• W1971758359 hasConceptScore W1971758359C105702510 @default.
• W1971758359 hasConceptScore W1971758359C141071460 @default.
• W1971758359 hasConceptScore W1971758359C171056886 @default.
• W1971758359 hasConceptScore W1971758359C199343813 @default.
• W1971758359 hasConceptScore W1971758359C2776206872 @default.
• W1971758359 hasConceptScore W1971758359C2781411149 @default.
• W1971758359 hasConceptScore W1971758359C71924100 @default.
• W1971758359 hasConceptScore W1971758359C86803240 @default.
• W1971758359 hasConceptScore W1971758359C95444343 @default.
• W1971758359 hasIssue "1" @default.
• W1971758359 hasLocation W19717583591 @default.
• W1971758359 hasLocation W19717583592 @default.

• next