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• W1971764494 startingPage "1045" @default.
• W1971764494 abstract "Lithotripsy is a common effective treatment for kidney stones. However, focal volumes are often larger than stones, and surrounding tissue is often injured. Our goal was to test in vitro a new lithotripter consisting of two opposing, confocal and simultaneously triggered electrohydraulic sources. The pulses superimpose at the common focus, resulting in pressure doubling and enhanced cavitation growth in a localized, approximately 1-cm wide volume. Model gypsum stones and human erythrocytes were exposed to dual pulses or single pulses. At the focus, model stones treated with 100 dual pulses at a charging voltage of 15 kV broke into 8 times the number of fragments as stones treated with 200 single pulses at 18 kV. At axial positions 2 and 4 cm away from the focus, lysis of erythrocytes was reduced or equivalent for dual pulses vs. single pulses. Hence, in half the time, dual pulses increased comminution at the focus without increasing injury in surrounding regions." @default.
• W1971764494 created "2016-06-24" @default.
• W1971764494 creator A5014222941 @default.
• W1971764494 creator A5074808223 @default.
• W1971764494 creator A5012834437 @default.
• W1971764494 date "2003-07-01" @default.
• W1971764494 modified "2023-10-03" @default.
• W1971764494 title "Dual-pulse lithotripter accelerates stone fragmentation and reduces cell lysis in vitro" @default.
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• W1971764494 doi "https://doi.org/10.1016/s0301-5629(03)00887-1" @default.
• W1971764494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12878251" @default.
• W1971764494 hasPublicationYear "2003" @default.
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