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- W1971776982 abstract "This is a matched case-control study, using spontaneously reported data, to examine the effect of concomitant oral contraceptives on hypertriglyceridemia (HTG) and hypercholesterolemia (HCHL) among female patients who received isotretinoin therapy. Study subjects included all female isotretinoin users, aged 15 to 55, who experienced an adverse event following isotretinoin therapy and were reported to the manufacturer between January 1, 1982 and July 31, 1993. Cases were women who experienced HTG, HCHL, or both and were further classified into three groups ‘HTG only’, ‘HCHL only’, and ‘both HTG and HCHL’. Controls were women who experienced any adverse events other than HTG, HCHL, alopecia, diabetes mellitus, pancreatitis, and obesity. Two controls were randomly selected to match with each case by age (+/- 2 years) and by year of commencement of isotretinoin therapy. Statistically significant association was observed between concomitant OC use and HTG (OR = 3.36, 95 per cent CI = 1.30–8.65) as well as between concomitant OC use and HCHL (OR = 2.30, 95 per cent CI = 1.36–3.87) among female isotretinoin users. There was an unusual high frequency of concomitant OC use (OR = 12.0, 95 per cent CI = 3.12–45.36) among ‘both HTG and HCHL’ patients comparing to that of controls. These results suggest a possible interactive effect between oral contraceptives and isotretinoin on the elevation of serum triglyceride or cholesterol levels." @default.
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- W1971776982 date "1995-03-01" @default.
- W1971776982 modified "2023-09-22" @default.
- W1971776982 title "Elevation of serum triglyceride and cholesterol levels from isotretinoin therapy with concomitant oral contraceptives" @default.
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- W1971776982 doi "https://doi.org/10.1002/pds.2630040204" @default.
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