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• W1971782783 abstract "The melanocortin-4 receptor (MC4R) is involved in feed intake regulation. A missense mutation G/A in position 1426, which causes Asp-Asn substitution at position 298 in the MC4R gene has been associated with feed intake, fatness and growth, however published results of its effect are inconsistent. In our study we evaluated an effect of missense mutations on carcass composition, growth traits and meat quality in 1191 gilts of five breeds: Polish Large White, Polish Landrace, Puławska, Pietrain and Duroc. G/A 1426 MC4R mutations were genotyped using a 7500 Real-Time PCR System (Applied Biosystem). Our observations confirm that the G allele is frequent in breeds selected for lean meat content (Pietrain – 92.4%) and rare in breed with a fat carcass (Duroc – 31.5%), which has been previously reported. Our study revealed that the A allele was associated with increased daily feed intake (AA – 2.51 kg; GG – 2.31 kg in the Puławska breed, P < 0.05), daily gain and backfat thickness (AA – 1.67 cm, GG – 1.52 cm in PL, P < 0.01) and decreased lean meat content (total weight of ham was 0.5 kg greater in G/G than in A/A Puławska animals). We obtained an unexpected result for IMF: higher percentage of IMF was observed in the G/G genotype." @default.
• W1971782783 created "2016-06-24" @default.
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• W1971782783 date "2010-06-01" @default.
• W1971782783 modified "2023-09-30" @default.
• W1971782783 title "Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland" @default.
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• W1971782783 doi "https://doi.org/10.1016/j.meatsci.2010.01.017" @default.
• W1971782783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20374902" @default.
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