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- W1971783617 abstract "The presence of the APOE ε 4 allele is a well established risk factor for Alzheimer's disease (AD) and has been associated with a faster progression of cognitive and functional decline. In addition, low levels of BDNF can be harmful to cognition. Conversely, physical activity has been shown to exert a protective effect against cognitive deterioration in late life, particularly among individuals who have undertaken regular aerobic exercises since adulthood and midlife. The interaction between physical activity and the APOE genotype on the risk of dementia has been addressed by epidemiological studies, indicating an unfavorable effect of the APOE ε 4 allele. 47 non-demented older adults were randomized into groups: exercise group (EG, n=30) and control group (CG, n=17). Participants were genotyped for APOE and classified according to the presence of the ε4 allele (APOE ε 4 carriers and noncarriers). The intervention consisted in an aerobic training program that was administered for 16 weeks (EG), whereas subjects in the CG participated in all assessments as per the protocol, but remained in a waiting list to start the exercise program after the completion of the trial. Primary outcome measures were changes in the performance the BDNF serum levels. A different pattern of response was observed according to the APOE genotype. Among APOE ε4 noncarriers, subjects in the EG had a significant improvement both in BDNF serum levels. Conversely, noncarriers from the CG had a significant impairment in the BDNF serum levels. No significant differences on cognitive or motor performance were observed among carriers, irrespective if receiving or not the intervention. The benefit from aerobic exercise training on BDNF serum levels was restricted to the sub-sample of APOE ε4 non-carriers. Therefore, the presence of the APOE ε4 allele may preclude certain biological responses that mediate the effects of aerobic exercise on cognition in older adults." @default.
- W1971783617 created "2016-06-24" @default.
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- W1971783617 date "2014-07-01" @default.
- W1971783617 modified "2023-10-14" @default.
- W1971783617 title "P4-071: APOLIPOPROTEIN E-ɛ4 MODULATES EFFECTS OF AEROBIC EXERCISE ON BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN NON-DEMENTED OLDER ADULTS" @default.
- W1971783617 doi "https://doi.org/10.1016/j.jalz.2014.05.1586" @default.
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