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• W1971789512 abstract "<i>Background:</i> Cell-mediated immunity is critical for controlling infection and preventing reactivation during the chronic phase of <i>Toxoplasma gondii</i> infection. In people suffering from AIDS, <i>T. gondii</i> is one of the major opportunistic infectious agents. Mechanisms regulating rapid development of clinical signs in previously asymptomatic patients remain unclear; however, cofactors such as stress are suspected to play a role in the susceptibility to opportunistic infections. <i>Objective:</i> This study examined the role of cold stress (CS) in splenocyte function during chronic <i>T. gondii</i> infection. <i>Methods:</i> Control mice and mice previously infected orally with <i>T. gondii</i> were subjected to CS during the chronic phase (CSchr), i.e. 90 days after infection, and in vitro cell proliferation and cytokine production were measured before (day 0) and 1, 15 and 25 days after CSchr. Splenocyte proliferation and cytokine production were measured after in vitro stimulation with concanavalin A (Con-A), anti-CD3 antibody (A-CD3) and <i>Toxoplasma</i> lysate antigen. <i>Results:</i> CSchr enhanced splenocyte proliferation in cells stimulated with Con-A and A-CD3, but it suppressed proliferation in cells stimulated with <i>T. gondii</i> antigens. Increased levels of interferon (IFN)-γ were detected independent of the type of stimulation after CSchr and remained high throughout the experiment. CS had similar results in noninfected animals. <i>Conclusion:</i> Although an overall increase in splenocyte function occurred after nonspecific stimulation, CS suppressed primed spleen cells from responding to <i>T. gondii </i>antigens which could lead to reactivation of latent infection. The increase in IFN-γ after CSchr could be a result of spleen cells being primed by released parasites by this stressor. IFN-γ is critical in the control of parasite reactivation." @default.
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• W1971789512 date "2004-01-01" @default.
• W1971789512 modified "2023-09-27" @default.
• W1971789512 title "Effects of Cold Stress on Spleen Cell Proliferation and Cytokine Production during Chronic <i>Toxoplasma gondii </i>Infection" @default.
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• W1971789512 doi "https://doi.org/10.1159/000075318" @default.
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