Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971809609> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1971809609 abstract "Background: Interferon-α (IFN-α) is a therapeutic option in high risk patients with Myeloproliferative Neoplasms (MPNs). The response to IFN-α treatment of chronic hepatitis C was shown to be strongly influenced by several related single nucleotide polymorphisms (SNP) in a region adjacent to the IL28B gene. The objective of this study was to investigate the possibility of similar influence of IL28B gene polymorphism in IFN-α treated MPN patients. Methods: 20 patients with polycythemia vera (PV) or essential thrombocythemia (ET) treated with IFN-α included, 7 were earlier treated with hydroxyurea. Hematologic response was evaluated using the European Leukemia Net (ELN) criteria. DNA from whole blood samples was isolated using MagNA Pure LC DNA Isolation Kit I for IL28B genotyping, and the variability at rs12979860, rs12980275 and rs8099917 were determined by allelic discrimination assays using Taqman minor groove binding probes. Results: The IFN-α treatment reduced platelet count ( p <0.05), and in patients with polycythemia vera (PV) also hemoglobin, hematocrit and white blood cell counts declined ( p <0.05). Hematologic response by ELN criteria was significantly influenced by the IL28B SNP. Among 20 patients with PV or ET, the CC genotype at rs12979860 was found in 8/11 patients (73%) with hematologic CR as compared with 1/9 (11%) with PR or NR ( p =0.010). Conclusion: The results in this pilot study indicate that variation in IL28B genotype might influence hematologic response in IFN-α treated MPN patients." @default.
- W1971809609 created "2016-06-24" @default.
- W1971809609 creator A5032642692 @default.
- W1971809609 creator A5048497439 @default.
- W1971809609 creator A5050197133 @default.
- W1971809609 creator A5055032084 @default.
- W1971809609 creator A5066772724 @default.
- W1971809609 creator A5073871579 @default.
- W1971809609 date "2012-09-04" @default.
- W1971809609 modified "2023-10-02" @default.
- W1971809609 title "Influence of interferon-α treatment outcome in polycythemia vera and essential thrombocythemia by genetic polymorphism in IL28B" @default.
- W1971809609 cites W1968468753 @default.
- W1971809609 cites W1973309978 @default.
- W1971809609 cites W1985177017 @default.
- W1971809609 cites W1987009823 @default.
- W1971809609 cites W2001781369 @default.
- W1971809609 cites W2017013905 @default.
- W1971809609 cites W2021797151 @default.
- W1971809609 cites W2024706907 @default.
- W1971809609 cites W2026614040 @default.
- W1971809609 cites W2027613124 @default.
- W1971809609 cites W2034045161 @default.
- W1971809609 cites W2042754952 @default.
- W1971809609 cites W2056418842 @default.
- W1971809609 cites W2058538904 @default.
- W1971809609 cites W2063285149 @default.
- W1971809609 cites W2079611196 @default.
- W1971809609 cites W2086414517 @default.
- W1971809609 cites W2094456737 @default.
- W1971809609 cites W2097652536 @default.
- W1971809609 cites W2103152966 @default.
- W1971809609 cites W2110809498 @default.
- W1971809609 cites W2147349522 @default.
- W1971809609 cites W2157135427 @default.
- W1971809609 cites W2157961528 @default.
- W1971809609 doi "https://doi.org/10.5430/jhm.v2n3p18" @default.
- W1971809609 hasPublicationYear "2012" @default.
- W1971809609 type Work @default.
- W1971809609 sameAs 1971809609 @default.
- W1971809609 citedByCount "0" @default.
- W1971809609 crossrefType "journal-article" @default.
- W1971809609 hasAuthorship W1971809609A5032642692 @default.
- W1971809609 hasAuthorship W1971809609A5048497439 @default.
- W1971809609 hasAuthorship W1971809609A5050197133 @default.
- W1971809609 hasAuthorship W1971809609A5055032084 @default.
- W1971809609 hasAuthorship W1971809609A5066772724 @default.
- W1971809609 hasAuthorship W1971809609A5073871579 @default.
- W1971809609 hasBestOaLocation W19718096091 @default.
- W1971809609 hasConcept C104317684 @default.
- W1971809609 hasConcept C126322002 @default.
- W1971809609 hasConcept C135763542 @default.
- W1971809609 hasConcept C153209595 @default.
- W1971809609 hasConcept C203014093 @default.
- W1971809609 hasConcept C2778837598 @default.
- W1971809609 hasConcept C2780959883 @default.
- W1971809609 hasConcept C2781057849 @default.
- W1971809609 hasConcept C31467283 @default.
- W1971809609 hasConcept C54355233 @default.
- W1971809609 hasConcept C71924100 @default.
- W1971809609 hasConcept C86803240 @default.
- W1971809609 hasConcept C90924648 @default.
- W1971809609 hasConceptScore W1971809609C104317684 @default.
- W1971809609 hasConceptScore W1971809609C126322002 @default.
- W1971809609 hasConceptScore W1971809609C135763542 @default.
- W1971809609 hasConceptScore W1971809609C153209595 @default.
- W1971809609 hasConceptScore W1971809609C203014093 @default.
- W1971809609 hasConceptScore W1971809609C2778837598 @default.
- W1971809609 hasConceptScore W1971809609C2780959883 @default.
- W1971809609 hasConceptScore W1971809609C2781057849 @default.
- W1971809609 hasConceptScore W1971809609C31467283 @default.
- W1971809609 hasConceptScore W1971809609C54355233 @default.
- W1971809609 hasConceptScore W1971809609C71924100 @default.
- W1971809609 hasConceptScore W1971809609C86803240 @default.
- W1971809609 hasConceptScore W1971809609C90924648 @default.
- W1971809609 hasIssue "3" @default.
- W1971809609 hasLocation W19718096091 @default.
- W1971809609 hasOpenAccess W1971809609 @default.
- W1971809609 hasPrimaryLocation W19718096091 @default.
- W1971809609 hasRelatedWork W1482355610 @default.
- W1971809609 hasRelatedWork W1975755087 @default.
- W1971809609 hasRelatedWork W1978735379 @default.
- W1971809609 hasRelatedWork W1984010596 @default.
- W1971809609 hasRelatedWork W2029743397 @default.
- W1971809609 hasRelatedWork W2164332050 @default.
- W1971809609 hasRelatedWork W2387442301 @default.
- W1971809609 hasRelatedWork W2494633032 @default.
- W1971809609 hasRelatedWork W2903749170 @default.
- W1971809609 hasRelatedWork W2340075867 @default.
- W1971809609 hasVolume "2" @default.
- W1971809609 isParatext "false" @default.
- W1971809609 isRetracted "false" @default.
- W1971809609 magId "1971809609" @default.
- W1971809609 workType "article" @default.